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Complement C3 Convertase, Classical Pathway

Known as: Classical Pathway C3 Convertase, C3 Convertase (C4b2a), Classical C3 Convertase 
A serine protease that cleaves multiple COMPLEMENT 3 into COMPLEMENT 3A (anaphylatoxin) and COMPLEMENT 3B in the CLASSICAL COMPLEMENT ACTIVATION… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The complement system plays an essential protective role in the initial defense against many microorganisms. Flavivirus NS1 is a… Expand
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2007
2007
Activation of component C3 is central to the pathways of complement and leads directly to neutralization of pathogens and… Expand
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Highly Cited
1992
Highly Cited
1992
A major protein secreted by vaccinia virus-infected cells has structural similarity to the super-family of complement-control… Expand
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1992
1992
A unique thioester bond, formed between the side chains of neighboring C and Q residues, is present in complement components C3… Expand
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1987
1987
C4 nephritic factor (C4NeF) was found in the serum of a patient with chronic glomerulonephritis, whose C3 level was quite low… Expand
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1987
1987
The fluid phase C3 convertase of the alternative pathway of human complement activation has been constructed from the isolated C3… Expand
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1981
1981
A protein with decay-accelerating activity for the classical C3 convertase, C4b2a, has been isolated on the basis of this… Expand
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1981
1981
Three mechanisms that regulate the formation and function of the classical pathway C3 convertase (C4b2a) have been elucidated: (a… Expand
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1980
1980
The assembly of the classical pathway C3 convertase in the fluid phase has been studied. The enzyme is assembled from C2 and C4… Expand
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