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Complement C3 Convertase, Classical Pathway

Known as: Classical Pathway C3 Convertase, C3 Convertase (C4b2a), Classical C3 Convertase 
A serine protease that cleaves multiple COMPLEMENT 3 into COMPLEMENT 3A (anaphylatoxin) and COMPLEMENT 3B in the CLASSICAL COMPLEMENT ACTIVATION… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The complement system plays an essential protective role in the initial defense against many microorganisms. Flavivirus NS1 is a… Expand
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Highly Cited
2007
Highly Cited
2007
Activation of component C3 is central to the pathways of complement and leads directly to neutralization of pathogens and… Expand
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Highly Cited
1992
Highly Cited
1992
A major protein secreted by vaccinia virus-infected cells has structural similarity to the super-family of complement-control… Expand
Highly Cited
1992
Highly Cited
1992
A unique thioester bond, formed between the side chains of neighboring C and Q residues, is present in complement components C3… Expand
1992
1992
In general, C4A allotypes of human C4 show one-fourth to one-third the hemolytic activity of C4B allotypes. An exception to this… Expand
1987
1987
C4 nephritic factor (C4NeF) was found in the serum of a patient with chronic glomerulonephritis, whose C3 level was quite low… Expand
1987
1987
: The fluid phase C3 convertase of the alternative pathway of human complement activation has been constructed from the isolated… Expand
1987
1987
The fluid phase C3 convertase of the alternative pathway of human complement activation has been constructed from the isolated C3… Expand
Highly Cited
1981
Highly Cited
1981
A protein with decay-accelerating activity for the classical C3 convertase, C4b2a, has been isolated on the basis of this… Expand
Highly Cited
1980
Highly Cited
1980
  • M. Kerr
  • The Biochemical journal
  • 1980
  • Corpus ID: 24619869
The assembly of the classical pathway C3 convertase in the fluid phase has been studied. The enzyme is assembled from C2 and C4… Expand
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