• Publications
  • Influence
Idiopathic membranoproliferative glomerulonephritis in childhood
  • C. West
  • Medicine
  • Pediatric Nephrology
  • 2004
Membranoproliferative glomerulonephritis (MPGN), recognized since 1965, is now known to have three forms, designated types I, II, and III. The types are similar in the frequency of hypocomplementemiaExpand
  • 67
  • 6
Serum C'3 Lytic System in Patients with Glomerulonephritis
The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the thirdExpand
  • 214
  • 5
Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis.
Acute poststreptococcal glomerulonephritis (AGN) differed from membranoproliferative glomerulonephritis (MPGN) and lupus nephritis (SLE) in that two of the proteins that control the C3b-dependentExpand
  • 49
  • 3
A properdin dependent nephritic factor slowly activating C3, C5, and C9 in membranoproliferative glomerulonephritis, types I and III.
The IgG fraction of serum from patients with membranoproliferative glomerulonephritis (MPGN) types I and III was found to contain a nephritic factor (NFI/III) which differed from that usually presentExpand
  • 44
  • 3
Paramesangial glomerular deposits in membranoproliferative glomerulonephritis type II correlate with hypocomplementemia.
To gain support for a previously proposed hypothesis that nephritic factors predispose to chronic glomerulonephritis, the glomerular deposits of patients with membranoproliferative glomerulonephritisExpand
  • 20
  • 3
Hypocomplementemic and normocomplementemic persistent chronic glomerulonephritis. Clinical and pathologic characteristics
Of 24 patients with nephritis of duration over one year, 17, consistently, over long periods, had normal levels of serum β 1C -globulin and 7, consistently, had reduced levels. Levels of serumExpand
  • 202
  • 2
Patterns of complement activation in idiopathic membranoproliferative glomerulonephritis, types I, II, and III.
Complement profiles on 22 hypocomplementemic patients with membranoproliferative glomerulonephritis (MPGN) type I, on 11 with MPGN II, and on 16 with MPGN III, gave evidence that the nephritic factorExpand
  • 55
  • 2
An inherited defect in the C3 convertase, C3b,Bb, associated with glomerulonephritis.
The control of the amplification C3 convertase, C3b,Bb, of the serum complement system has been found to be defective in five members of a family spanning three generations. One of the five hasExpand
  • 48
  • 2
Nephritic factors predispose to chronic glomerulonephritis.
  • C. West
  • Medicine
  • American journal of kidney diseases : the…
  • 1 December 1994
Chronic glomerulonephritis has been reported in three rare conditions in which factor H of the complement system does not function normally. Factor H is essential for the inactivation of theExpand
  • 49
  • 2
The Effect of Prednisone in a High‐Dose, Alternate‐Day Regimen on the Natural History of Idiopathic Membranoproliferative Glomerulonephritis
Experience in 45 children with diffuse proliferative MPGN of all three types has provided evidence that a high-dose, alternate-day regimen of prednisone alters the natural history of the disease. TheExpand
  • 29
  • 2