Clostridium difficile (bacteria)

Known as: Peptoclostridium difficile, Clostridium difficile, [Clostridium] difficile 
A type of bacterium found in human and animal waste. Clostridium difficile is a common cause of diarrhea that occurs in hospitals. It can also cause… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
010020030019462016

Related topics

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17 relations
CDISC SDTM Microorganism TerminologyClinical Data Interchange Standards Consortium TerminologyClostridium difficile Ab.IgA:ACnc:Pt:Ser:QnClostridium difficile Ab.IgG:ACnc:Pt:Ser:Qn
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Broader (1)

Clostridium

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Clostridium difficile (bacteria)
physiological aspects
CDISC SDTM Microorganism Terminology
Clostridium
Clostridium difficile toxin B:PrThr:Pt:Stool:Ord
Enterocolitis, Pseudomembranous

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Integration of metabolism and virulence in Clostridium difficile.
Synthesis of the major toxin proteins of the diarrheal pathogen, Clostridium difficile, is dependent on the activity of TcdR, an… (More)
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Highly Cited
2014
Highly Cited
2014
Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection.
Fecal microbiota transplantation (FMT) has emerged as a highly effective therapy for refractory, recurrent Clostridium difficile… (More)
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Highly Cited
2014
Highly Cited
2014
Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study.
BACKGROUND Recurrent Clostridium difficile infection (CDI) with poor response to standard antimicrobial therapy is a growing… (More)
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Highly Cited
2009
Highly Cited
2009
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.
Clostridium difficile persists in hospitals by exploiting an infection cycle that is dependent on humans shedding highly… (More)
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Highly Cited
2008
Highly Cited
2008
Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus…
Using 42 isolates contributed by laboratories in Canada, The Netherlands, the United Kingdom, and the United States, we compared… (More)
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Highly Cited
2007
Highly Cited
2007
The emerging infectious challenge of clostridium difficile-associated disease in Massachusetts hospitals: clinical and economic consequences.
OBJECTIVE To estimate the clinical and economic burden of Clostridium difficile-associated disease (CDAD) in Massachusetts over 2… (More)
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Highly Cited
2005
Highly Cited
2005
Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR.
To determine the influence of either exclusive breast-feeding or formula feeding on both composition and quantity of the gut… (More)
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Highly Cited
2004
Highly Cited
2004
Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (Toxin A), and tcdB (Toxin B) genes for toxigenic culture of Clostridium difficile.
A multiplex PCR toxigenic culture approach was designed for simultaneous identification and toxigenic type characterization of… (More)
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Highly Cited
1999
Highly Cited
1999
PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes.
A reference library of types of Clostridium difficile has been constructed by PCR ribotyping isolates (n = 2,030) from… (More)
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Highly Cited
1998
Highly Cited
1998
A novel toxinotyping scheme and correlation of toxinotypes with serogroups of Clostridium difficile isolates.
Two hundred nineteen Clostridium difficile isolates from 22 serogroups were screened for changes in the genes coding for toxin B… (More)
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