FAQ

Cingulin-Like Protein 1

Known as: CGNL1, Junction-Associated Coiled-Coil Protein, Paracingulin 
Cingulin-like protein 1 (1302 aa, ~149 kDa) is encoded by the human CGNL1 gene. This protein plays a role in the organization of tight junctions.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2016
01220082016

Related topics

Related topics

3 relations
CGNL1 geneStructural geneTight Junctions

Related mentions per year

Related mentions per year

1951-2018
1960198020002020
Cingulin-Like Protein 1
Tight Junctions
Structural gene
CGNL1 gene

Papers overview

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2016
2016
Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas.
Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior… (More)
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2014
2014
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
Large and rare copy number variants (CNVs) at several loci have been shown to increase risk for schizophrenia. Aiming to discover… (More)
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2014
2014
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly
The regulation of Rho-family GTPases is crucial to direct the formation of cell-cell junctions and tissue barriers. Cingulin (CGN… (More)
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2013
2013
The Junctional Proteins Cingulin and Paracingulin Modulate the Expression of Tight Junction Protein Genes through GATA-4
The cytoplamic junctional proteins cingulin and paracingulin have been implicated in the regulation of gene expression in… (More)
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2012
2012
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
Paracingulin is an M(r) 150-160 kDa cytoplasmic protein of vertebrate epithelial tight and adherens junctions and comprises… (More)
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2011
2011
A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
Paracingulin is a 160-kDa protein localized in the cytoplasmic region of epithelial tight and adherens junctions, where it… (More)
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2011
2011
Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
Cingulin (CGN) and paracingulin (CGNL1) are structurally related proteins that regulate Rho family GTPases by recruiting guanine… (More)
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2008
2008
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
Small GTPases control key cellular events, including formation of cell-cell junctions and gene expression, and are regulated by… (More)
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