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Cilengitide

Known as: cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl) 
A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Cilengitide is a selective αvβ3 and αvβ5 integrin inhibitor. Data from phase 2 trials suggest that it has antitumour… Expand
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Highly Cited
2012
Highly Cited
2012
This paper discusses the role of peptides in cancer therapy with special emphasis on peptide drugs which are already approved and… Expand
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Highly Cited
2011
Highly Cited
2011
Cilengitide is a cyclic pentapeptide that is a specific inhibitor of the αvβ3 and αvβ5 integrins. Preclinical studies demonstrate… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Invasion and migration are key processes of glioblastoma and are tightly linked to tumor recurrence. Integrin inhibition… Expand
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Review
2010
Review
2010
The integrin family of cell adhesion receptors regulates a diverse array of cellular functions crucial to the initiation… Expand
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Highly Cited
2010
Highly Cited
2010
Purpose: Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using… Expand
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Highly Cited
2009
Highly Cited
2009
Cilengitide is a high-affinity cyclic pentapeptdic αV integrin antagonist previously reported to suppress angiogenesis by… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE Cilengitide, an inhibitor of alphavbeta3 and alphavbeta5 integrin receptors, demonstrated minimal toxicity and durable… Expand
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Highly Cited
2007
Highly Cited
2007
PURPOSE This multi-institutional phase I trial was designed to determine the maximum-tolerated dose (MTD) of cilengitide (EMD… Expand
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Highly Cited
2002
Highly Cited
2002
Although metastatic breast cancer is responsive to radioimmunotherapy (RIT), a systemictargeted radiation modality, complete and… Expand
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