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Cilengitide

Known as: cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl) 
A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and… 
National Institutes of Health

Related topics

Related topics

9 relations
Angiogenesis InhibitionCell Adhesion InhibitionEndothelium, VascularIntegrin Inhibition

Narrower (1)

EMD 121974

Broader (1)

Snake Venoms

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The interventional effect of new drugs combined with the Stupp protocol on glioblastoma: A network meta-analysis
2014
2014
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure.
The X-ray crystal and NMR spectroscopic structures of the peptide drug candidate Cilengitide (cyclo(RGDf(NMe)Val)) in various… 
2014
2014
Cilengitide, a small molecule antagonist, targeted to integrin αν inhibits proliferation and induces apoptosis of laryngeal cancer cells in vitro
Cilengitide is a chemical synthesis cyclopeptide containing RGD sequence, which can be used as a small molecule antagonist… 
Highly Cited
2013
Highly Cited
2013
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: Key results of the multicenter…
LBA2009 Background: Cilengitide (CIL) is a selective αvβ3 and αvβ5 integrin inhibitor. In a phase II study in patients with newly… 
2013
2013
Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: a report from the Children's Oncology Group.
BACKGROUND Cilengitide, an αv integrin antagonist, has demonstrated activity in recurrent adult glioblastoma (GBM). The Children… 
2011
2011
Cilengitide inhibits metastatic bone colonization in a nude rat model.
Integrins αvβ3 and αvβ5 are considered to play an important role in the pathogenesis of breast cancer bone metastases. This study… 
2011
2011
STD and trNOESY NMR Study of Receptor–Ligand Interactions in Living Cancer Cells
Integrins are transmembrane receptors that link the cytoskeleton to the extracellular matrix (ECM), mediating cell–cell and cell… 
Highly Cited
2011
Highly Cited
2011
Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma
Review
2011
Review
2011
Targets for therapy in ependymoma
Ependymomas are among the rarest type of glioma and display significant heterogeneity based on patient age and tumor location… 
Review
2009
Review
2009
Antiangiogenic strategies for treatment of malignant gliomas
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