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New treatments have improved outcomes for patients with relapsed chronic lymphocytic leukemia (CLL), but complete… Expand BACKGROUND
Fluorescence in situ hybridization has improved the detection of genomic aberrations in chronic lymphocytic leukemia… Expand BACKGROUND/METHODS
Gliomas are common malignant neoplasms of the central nervous system. Among the major subtypes of gliomas… Expand Colorectal tumor DNA was examined for somatic instability at (CA)n repeats on human chromosomes 5q, 15q, 17p, and 18q… Expand HEPATOCELLULAR carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and eastern Asia1. Hepatitis B virus and aflatoxins… Expand Charcot-Marie-tooth disease type 1A (CMT1A) was localized by genetic mapping to a 3 cM interval on human chromosome 17p. DNA… Expand Coordinate loss of one copy of the p53 gene and mutation of the remaining copy occur in colorectal carcinomas and in many other… Expand Previous studies have demonstrated that allelic deletions of the short arm of chromosome 17 occur in over 75% of colorectal… Expand THE p53 gene has been a constant source of fascination since its discovery nearly a decade ago1,2. Originally considered to be an… Expand A clone that cross-hybridizes with a mouse p53 probe has been isolated from a cDNA library of simian virus 40-transformed human… Expand