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Genetic control of the cell division cycle in yeast.
TLDR
Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle. Expand
Cancer as an evolutionary and ecological process
TLDR
The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer. Expand
A critical review of the diagnosis and management of Barrett's esophagus: the AGA Chicago Workshop.
TLDR
Based on this review of BE, the opinions of workshop members on issues pertaining to screening and surveillance are at variance with published clinical guidelines. Expand
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
TLDR
It is shown that clonal diversity measures adapted from ecology and evolution can predict progression to adenocarcinoma in the premalignant condition known as Barrett's esophagus, even when controlling for established genetic risk factors. Expand
Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
The public health importance of Barrett's oesophagus lies in its association with oesophageal adenocarcinoma. The incidence of oesophageal adenocarcinoma has risen at an alarming rate over the pastExpand
Observer variation in the diagnosis of dysplasia in Barrett's esophagus.
TLDR
It is concluded that experienced gastrointestinal morphologists can diagnose high-grade dysplasia and intramucosal carcinoma with a high degree of agreement and thus can detect those patients who may need immediate rebiopsy or esophageal resection. Expand
Early detection: The case for early detection
Early detection represents one of the most promising approaches to reducing the growing cancer burden. It already has a key role in the management of cervical and breast cancer, and is likely toExpand
Evolution of neoplastic cell lineages in Barrett oesophagus
TLDR
The evolutionary relationships of non-random LOH, TP53 and CD KN2A mutations, CDKN2A CpG-island methylation and ploidy during neoplastic progression are determined and indicate that clonal evolution is more complex than predicted by linear models. Expand
Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets
TLDR
A systematic baseline endoscopic biopsy protocol using histology and flow cytometry identifies subsets of patients with Barrett's esophagus at low and high risk for progression to cancer. Expand
NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Adenocarcinoma
TLDR
A combination of 17p Loh, 9p LOH, and DNA content abnormalities provided better EA risk prediction than any single TP53, CDKN2A, or DNA content lesion alone, and NSAIDs are associated with reduced EA risk, especially in patients with multiple high-risk molecular abnormalities. Expand
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