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Chimeric Monoclonal Antibody B72.3
Known as:
Chimeric B72.3
A synthetic chimeric molecule in which a mouse monoclonal antibody variable region directed against the tumor-associated glycoprotein 72 (TAG-72) is…
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National Institutes of Health
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Related topics
Related topics
1 relation
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Light-chain framework region residue Tyr71 of chimeric B72.3 antibody plays an important role in influencing the TAG72 antigen binding.
J. Xiang
,
L. Prasad
,
L. Delbaere
,
Z. Jia
Protein engineering
1999
Corpus ID: 25946123
The crystallographic study of chimeric B72.3 antibody illustrated that there are three FR side-chain interactions with either CDR…
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1996
1996
Complementarity determining region residues aspartic acid at H55, serine at H95 and tyrosines at H97 and L96 play important roles in the B72.3 antibody-TAG72 antigen interaction.
J. Xiang
,
Y. Sha
,
L. Prasad
,
L. Delbaere
Protein engineering
1996
Corpus ID: 29019314
Structural analysis derived from the crystallographic study of the chimeric B72.3 antibody illustrated some major atomic…
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1993
1993
Construction and purification of domain-deleted immunoglobulin variants of the recombinant/chimeric B72.3 (y1) monoclonal antibody.
B. Calvo
,
S. Kashmiri
,
+4 authors
S. Zaremba
Cancer biotherapy
1993
Corpus ID: 24706982
Chimeric antibodies have been produced against a pancarcinomic tumor associated antigen, TAG-72, by fusing the genes for the…
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1993
1993
Direct localization comparison of murine and chimeric B72.3 antibodies in patients with colon cancer.
R. Meredith
,
M. Khazaeli
,
+7 authors
J. Schlom
Human antibodies and hybridomas
1993
Corpus ID: 28756465
To compare radiolocalization of murine B72.3 (m-B72.3) and mouse/human chimeric B72.3 (ch-B72.3) antibodies, five patients with…
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1991
1991
Comparative biodistributions of Y-90 and In-111-macrocycle chimeric b72.3 conjugates in a human colon carcinoma xenograft model.
A. Farnsworth
,
A. Turner
,
+5 authors
R. Boden
1991
Corpus ID: 56599386
1990
1990
Production of murine V-human Cr1 chimeric anti-TAG72 antibody using V region cDNA amplified by PCR.
J. Xiang
,
J. Roder
,
N. Hozumi
Molecular immunology
1990
Corpus ID: 11942088
1990
1990
A preliminary investigation of the hydrodynamic properties of two novel monoclonal antibodies.
O. Byron
,
S. Harding
,
S. Rhind
Biochemical Society transactions
1990
Corpus ID: 8708807
B72.3 is a murine monoclonal antibody which reacts with a range o f ovarian, breast and colon carcinomas. Its immunoscintigraphic…
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1990
1990
Rapid clearance of aglycosyl recombinant chimeric B72.3 (4) antibody in athymic mice bearing human colorectal xenografts
S. Rhind
,
D. King
,
+8 authors
D. Secher
1990
Corpus ID: 64775595
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