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Chimeric Monoclonal Antibody B72.3

Known as: Chimeric B72.3 
A synthetic chimeric molecule in which a mouse monoclonal antibody variable region directed against the tumor-associated glycoprotein 72 (TAG-72) is… Expand
National Institutes of Health

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Related topics

1 relation
antigen binding

Papers overview

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1999
1999
Light-chain framework region residue Tyr71 of chimeric B72.3 antibody plays an important role in influencing the TAG72 antigen binding.
The crystallographic study of chimeric B72.3 antibody illustrated that there are three FR side-chain interactions with either CDR… Expand
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1996
1996
Complementarity determining region residues aspartic acid at H55, serine at H95 and tyrosines at H97 and L96 play important roles in the B72.3 antibody-TAG72 antigen interaction.
Structural analysis derived from the crystallographic study of the chimeric B72.3 antibody illustrated some major atomic… Expand
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1993
1993
Construction and purification of domain-deleted immunoglobulin variants of the recombinant/chimeric B72.3 (y1) monoclonal antibody.
Chimeric antibodies have been produced against a pancarcinomic tumor associated antigen, TAG-72, by fusing the genes for the… Expand
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1993
1993
Direct localization comparison of murine and chimeric B72.3 antibodies in patients with colon cancer.
To compare radiolocalization of murine B72.3 (m-B72.3) and mouse/human chimeric B72.3 (ch-B72.3) antibodies, five patients with… Expand
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1991
1991
Comparative biodistributions of Y-90 and In-111-macrocycle chimeric b72.3 conjugates in a human colon carcinoma xenograft model.
 
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1990
1990
Production of murine V-human Cr1 chimeric anti-TAG72 antibody using V region cDNA amplified by PCR.
A mouse/human chimeric B72.3-1-3 antibody was produced by construction of a novel expression vector mpSV2neo-EP1-V-Cr1. This… Expand
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1990
1990
A preliminary investigation of the hydrodynamic properties of two novel monoclonal antibodies.
B72.3 is a murine monoclonal antibody which reacts with a range o f ovarian, breast and colon carcinomas. Its immunoscintigraphic… Expand
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1990
1990
Rapid clearance of aglycosyl recombinant chimeric B72.3 (4) antibody in athymic mice bearing human colorectal xenografts
 
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