L. Delbaere

Publications196
h-index34
Citations3,947
Highly Influential Citations135
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Structure and Mechanism of Phosphoenolpyruvate Carboxykinase*
TLDR
This minireview will focus on new structural results derived from the recent crystal structure determinations of native E. coli PCK, its complex with ATP-Mg-oxalate, and the implications for the active site residues and catalytic mechanism of E.E. coli and other ATPand GTP-dependent PCKs.
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Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure.
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The nerve of ovulation-inducing factor in semen
TLDR
It is concluded that OIF in seminal plasma is β-NGF and that it is highly conserved and elucidates a previously unknown pathway for the direct influence of the male on the hypothalamo–pituitary–gonadal axis of the inseminated female.
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The structure of a universally employed enzyme: V8 protease from Staphylococcus aureus.
TLDR
The structure of V8 protease shows structural similarity with several other serine proteases, specifically the epidermolytic toxins A and B from S. aureus and trypsin, in which the conformation of the active site is almost identical.
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Structures of the lectin IV of Griffonia simplicifolia and its complex with the Lewis b human blood group determinant at 2.0 A resolution.
The structures of the fourth lectin isolated from Griffonia simplicifolia (GS4) and its complex with the methyl-glycoside of the Lewis b human blood group determinant (Le(b)-OMe) are reported at high…
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Trifluoperazine-induced conformational change in Ca2+-calmodulin
TLDR
It is shown that, as a consequence of binding the drug trifluoperazine, a major conformational movement occurs in Ca2+-calmodulin (CaM), which changes from an elongated dumb-bell, with exposed hydrophobic surfaces, to a compact globular form which can no longer interact with its target enzymes.
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Activation of the SspA Serine Protease Zymogen of Staphylococcus aureus Proceeds through Unique Variations of a Trypsinogen-like Mechanism and Is Dependent on Both Autocatalytic and…
TLDR
It is found that pre-zSspA is processed by signal peptidase at ANA29 ↓, releasing a Leu30 isoform that is first processed exclusively through autocatalytic intramolecular cleavage within a glutamine-rich propeptide segment, 40QQTQSSKQQTPKIQ53.
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Phylogenetic Study of the Evolution of PEP-Carboxykinase
TLDR
A flowchart of the evolution of PCK has been proposed and shows that the nucleotide binding sites are somewhat conserved within each class with few exceptions that do not have any clear ATP- or GTP-specific binding motif.
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Crystal structure of Escherichia coli phosphoenolpyruvate carboxykinase: a new structural family with the P-loop nucleoside triphosphate hydrolase fold.
TLDR
The crystal structure of ATP-dependent phosphoenolpyruvate carboxykinase (PCK) from Escherichia coli strain K12 has been determined using a combination of multiple isomorphous replacement, density modification, and partial model phase combination, suggesting it represents the first member in a new family of such proteins.
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The 2.0-A resolution structure of Escherichia coli histidine-containing phosphocarrier protein HPr. A redetermination.
TLDR
The semi-closed conformation observed in the E. coli HPr structure could represent a structural intermediate on the phosphorylation/dephosphorylation pathway of HPr, and is similar to other reported NMR and x-ray HPr structures.
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