Checkpoint Kinase Inhibitor AZD7762

A synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which… (More)
National Institutes of Health

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2012-2017
0120122017

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2017
2017
BACKGROUND More effective chemotherapies are urgently needed for bladder cancer, a major cause of morbidity and mortality… (More)
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2014
2014
OBJECTIVE Checkpoint kinase (Chk) inhibitors are thought to increase the cytotoxic effects of DNA-damaging agents and are… (More)
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2012
2012
DNA cross-linking agents are frequently used in the treatment of multiple myeloma-generating lesions, which activate checkpoint… (More)
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