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Checkpoint Kinase Inhibitor AZD7762

A synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which… (More)
National Institutes of Health

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2012-2017
0120122017

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AZD 7762

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2008-2018
20002005201020152020
Checkpoint Kinase Inhibitor AZD7762
AZD 7762

Papers overview

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2017
2017
Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
BACKGROUND More effective chemotherapies are urgently needed for bladder cancer, a major cause of morbidity and mortality… (More)
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2014
2014
Checkpoint kinase inhibitor AZD7762 overcomes cisplatin resistance in clear cell carcinoma of the ovary.
OBJECTIVE Checkpoint kinase (Chk) inhibitors are thought to increase the cytotoxic effects of DNA-damaging agents and are… (More)
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2012
2012
The checkpoint kinase inhibitor AZD7762 potentiates chemotherapy-induced apoptosis of p53-mutated multiple myeloma cells.
DNA cross-linking agents are frequently used in the treatment of multiple myeloma-generating lesions, which activate checkpoint… (More)
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