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AZD 7762
Known as:
AZD-7762
, AZD7762
National Institutes of Health
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Related topics
Related topics
1 relation
Checkpoint Kinase Inhibitor AZD7762
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma.
Muge Celiktas
,
I. Tanaka
,
+13 authors
A. Taguchi
Journal of the National Cancer Institute
2017
Corpus ID: 47240034
Background Liver kinase B1 ( LKB1 ) is a tumor suppressor in lung adenocarcinoma (LADC). We investigated the proteomic profiles…
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2015
2015
Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma
G. Magnussen
,
E. Emilsen
,
+5 authors
V. A. Flørenes
BMC Cancer
2015
Corpus ID: 18897917
Malignant melanoma has an increasing incidence rate and the metastatic disease is notoriously resistant to standard chemotherapy…
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2014
2014
Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.
Svetlana Grabauskiene
,
E. Bergeron
,
+5 authors
R. Reddy
Journal of Surgical Research
2014
Corpus ID: 27896730
2013
2013
A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy
Jun Zhou
,
Zhengming Chen
,
+4 authors
G. Bepler
PLoS ONE
2013
Corpus ID: 14723545
Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide…
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Highly Cited
2012
Highly Cited
2012
The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells
H. Landau
,
S. Mcneely
,
+6 authors
G. Schwartz
Molecular Cancer Therapeutics
2012
Corpus ID: 16274400
DNA cross-linking agents are frequently used in the treatment of multiple myeloma–generating lesions, which activate checkpoint…
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Highly Cited
2011
Highly Cited
2011
Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
L. A. Parsels
,
Y. Qian
,
+13 authors
M. Morgan
Clinical Cancer Research
2011
Corpus ID: 10538324
Purpose: Chk1 inhibitors, such as AZD7762, are in clinical development in combination with cytotoxic agents for the treatment of…
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2011
2011
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy.
Heekyoung Yang
,
S. Yoon
,
+5 authors
H. Yoo
Biochemical and Biophysical Research…
2011
Corpus ID: 6639938
2011
2011
Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death
Clint Mitchell
,
Hossein A. Hamed
,
+8 authors
P. Dent
Cancer Biology & Therapy
2011
Corpus ID: 207510422
The present studies were initiated to determine in greater molecular detail the regulation of CHK1 inhibitor lethality in…
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2011
2011
Phase I dose-escalation study of AZD7762 in combination with gemcitabine (gem) in patients (pts) with advanced solid tumors.
E. Sausville
,
P. LoRusso
,
+4 authors
A. Senderowicz
Journal of Clinical Oncology
2011
Corpus ID: 43112795
3058 Background: AZD7762, a potent Chk1/Chk2 inhibitor, has shown chemosensitizing activity with gem in preclinical xenograft…
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Highly Cited
2010
Highly Cited
2010
Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
S. Mcneely
,
C. Conti
,
+5 authors
A. Tse
Cell Cycle
2010
Corpus ID: 36113335
Checkpoint kinase 1 (Chk1) regulates cell cycle checkpoints and DNA damage repair in response to genotoxic stress. Inhibition of…
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