Cerebral Cavernous Malformations Protein

Known as: Krev Interaction Trapped 1, Cerebral Cavernous Malformations 1, Ankyrin Repeat-Containing Protein KRIT1 
Ankyrin Repeat-Containing Protein KRIT1, encoded by the CCM1 gene, interacts with ICAP-1 and may be involved in bidirectional signaling between… (More)
National Institutes of Health

Related topics

Related topics

15 relations
Angiogenic ProcessAnkyrin RepeatBinding ProteinsBrain
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology
Cerebral cavernous malformations (CCM) are neurovascular dysplasias that result in mulberry-shaped lesions predominantly located… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2009
Highly Cited
2009
A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells
Cavernous vascular malformations occur with a frequency of 1:200 and can cause recurrent headaches, seizures and hemorrhagic… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Genotype-phenotype correlations in cerebral cavernous malformations patients.
OBJECTIVE To compare clinical features of CCM1, CCM2, and CCM3 mutation carriers. METHODS A detailed clinical and molecular… (More)
Is this relevant?
Review
2006
Review
2006
Cerebral cavernous malformation: new molecular and clinical insights.
Cerebral cavernous malformation (CCM) is a vascular malformation causing neurological problems, such as headaches, seizures… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.
Hemorrhagic stroke is a significant cause of morbidity and mortality in children, and is frequently associated with intracranial… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
Mutations in KRIT1, a protein initially identified based on a yeast two-hybrid interaction with the RAS-family GTPase RAP1A, are… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations.
OBJECTIVES Cerebral cavernous malformations are linked to mutations of the KRIT1 gene at the CCM1 locus and to mutations at two… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).
Cerebral cavernous malformations (CCM) are congenital vascular anomalies of the brain that can cause significant neurological… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas
Cavernous angiomas are vascular malformations mostly located in the central nervous system and characterized by enlarged… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.
Cerebral cavernous malformation (CCM) is a Mendelian model of stroke, characterized by focal abnormalities in small intracranial… (More)
  • table 1
  • figure 1
  • figure 1
  • figure 1
  • figure 2
Is this relevant?