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Cephacetrile

Known as: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-((cyanoacetyl)amino)-8-oxo-, monosodium salt, (6R-trans)-, Cephacetrile [Chemical/Ingredient], Cefacetrilo 
A broad-spectrum first-generation cephalosporin with antibacterial activity. Cephacetrile binds to and inactivates penicillin-binding proteins (PBPs… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (1)

Anti-Bacterial Agents

Narrower (3)

CelosporCephacetrile SodiumFlunicef
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Comparative evaluation of cephacetrile in experimentally induced bovine mastitis.
Summary This work describes the development of a reproducible mastitis model in the milking cow. The model serves to compare… 
Highly Cited
1985
Highly Cited
1985
Studies on the promoting effects of carboxylic acid derivatives on the rectal absorption of beta-lactam antibiotics in rats.
The promoting effects of sodium salts of N-acyl-L-phenylalanines, p-substituted benzoic acids, saturated straight-chain fatty… 
1976
1976
Metabolic fate of cephacetrile after parenteral administration in rats and rabbits.
1. The metabolic fate of 14C-cephacetrile was studied in rats and rabbits. The plasma level of intravenously injected… 
1974
1974
Pharmacological studies on cephacetrile in human volunteers.
SummaryCephacetrile (7-cyanoacetamido-cephalosporanic acid sodium), a new injectable cephalosporin, was administered to healthy… 
1974
1974
Availability of three antibiotics after intramuscular injection into thigh and buttock.
1974
1974
Comparative Serum Levels and Protective Activity of Parenterally Administered Cephalosporins in Experimental Animals
Six cephalosporin antibiotics were administered subcutaneously to mice at a level of 20 mg/kg. The serum levels of each were… 
1973
1973
Biliary Excretion of a New Semisynthetic Cephalosporin, Cephacetrile
The biliary excretion of a new derivative of cephalosporin, cephacetrile (CIBA 36 278 Ba), was studied (i) in the isolated… 
1973
1973
Cephacetrile: Clinical Evaluation in 27 Patients
Cephacetrile, a new derivative of 7-aminocephalosporanic acid, was evaluated in 27 patients. Soft tissue infections due primarily… 
1972
1972
Effect of renal failure and hemodialysis on cephacetrile pharmacoki netics
Cephacetrile, a new injectable cephalosporin antibiotic that is allegedly not nephrotoxic, was evaluated in 15 subjects with… 
1972
1972
In vitro evaluation of cephacetrile, a new cephalosporin antibiotic.
Cephacetrile, 7-cyanacetamido-cephalosporanic acid, is a new cephalosporin active against many gram-positive and gram-negative… 
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