Cell-Free System

Known as: Cell-Free Systems, System, Cell-Free, Systems, Cellfree 
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given… (More)
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Highly Cited
2002
Highly Cited
2002
Generation of Interleukin (IL)-1beta via cleavage of its proform requires the activity of caspase-1 (and caspase-11 in mice), but… (More)
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Highly Cited
2002
Highly Cited
2002
We report a cell-free system for the high-throughput synthesis and screening of gene products. The system, based on the… (More)
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Highly Cited
1995
Highly Cited
1995
Cells performing V(D)J recombination make specific cuts in DNA at recombination signal sequences. Here, we show that nuclear… (More)
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Highly Cited
1994
Highly Cited
1994
THE infectious agent (or 'prion') of the transmissible spongiform encephalopathies (TSEs) such as scrapie resembles a virus in… (More)
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Highly Cited
1994
Highly Cited
1994
Apoptotic cell death involves a ritual series of morphological changes, presumably reflecting a conserved molecular pathway. We… (More)
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Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… (More)
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Highly Cited
1987
Highly Cited
1987
We have developed a cell-free system derived from Xenopus eggs that reconstitutes nuclear structure around an added protein-free… (More)
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Highly Cited
1986
Highly Cited
1986
We described a cell free system involving total homogenates of metaphase CHO cells, which yields telophase-like assembly of… (More)
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Highly Cited
1976
Highly Cited
1976
The effect of adriamycin on DNA, RNA, and protein synthesis was investigated in cell-free systems and intact cells. In studies… (More)
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