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Cefonicid

Known as: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Cefonicido, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1H-tetrazol-5-yl)thio)methyl)-, (6R-(6alpha,7beta(R*)))- 
A second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefonicid binds to penicillin-binding proteins… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND Allergy to cephalosporins has mainly been evaluated in the context of patients with confirmed penicillin allergy. The… Expand
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1993
1993
We compared cefonicid (2 g every 12 h) and ceftriaxone (2 g every 24 h) for their efficacy and safety in treating spontaneous… Expand
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1992
1992
The in-vitro activity of 24 beta-lactam antibiotics was compared using three groups of pneumococci and an agar dilution method… Expand
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1991
1991
A total of 1489 patients were included in a prospective, randomized study that compared the efficacy of a single dose of… Expand
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Highly Cited
1990
Highly Cited
1990
We assessed the efficacy of perioperative antibiotic prophylaxis for surgery in a randomized, double-blind trial of 1218 patients… Expand
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1984
1984
Cefonicid, a new long-acting cephalosporin, was evaluated for treatment of endocarditis due to Staphylococcus aureus. Four… Expand
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1984
1984
Fifteen patients with bone joint infections were treated with 1.0 g of cefonicid administered intravenously or intramuscularly… Expand
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1984
1984
In a randomized double-blind design, cefonicid, an investigational cephalosporin, was compared with cefazolin as prophylaxis in… Expand
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1984
1984
The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients… Expand
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1982
1982
This study determined the pharmacokinetic disposition of cefonicid. A single dose of 7.5 mg/kg of body weight was administered to… Expand
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