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Cefonicid

Known as: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Cefonicido, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1H-tetrazol-5-yl)thio)methyl)-, (6R-(6alpha,7beta(R*)))- 
A second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefonicid binds to penicillin-binding proteins… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND Allergy to cephalosporins has mainly been evaluated in the context of patients with confirmed penicillin allergy. The… Expand
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Highly Cited
1996
Highly Cited
1996
Although antimicrobial prophylaxis is mandatory in major clean‐contaminated oncologic surgery of the head and neck, both the… Expand
Highly Cited
1995
Highly Cited
1995
The epileptogenic activities of several beta-lactam antibiotics were compared following their intracerebroventricular… Expand
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Highly Cited
1993
Highly Cited
1993
We compared cefonicid (2 g every 12 h) and ceftriaxone (2 g every 24 h) for their efficacy and safety in treating spontaneous… Expand
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1991
1991
A total of 1489 patients were included in a prospective, randomized study that compared the efficacy of a single dose of… Expand
Highly Cited
1990
Highly Cited
1990
We assessed the efficacy of perioperative antibiotic prophylaxis for surgery in a randomized, double-blind trial of 1218 patients… Expand
Highly Cited
1984
Highly Cited
1984
Cefonicid, a new long-acting cephalosporin, was evaluated for treatment of endocarditis due to Staphylococcus aureus. Four… Expand
1984
1984
Fifteen patients with bone joint infections were treated with 1.0 g of cefonicid administered intravenously or intramuscularly… Expand
1982
1982
This study determined the pharmacokinetic disposition of cefonicid. A single dose of 7.5 mg/kg of body weight was administered to… Expand
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1981
1981
Cefonicid kinetics were determined after intravenous and intramuscular injection and the renal handling of the drug was examined… Expand