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Cefonicid

Known as: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Cefonicido, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1H-tetrazol-5-yl)thio)methyl)-, (6R-(6alpha,7beta(R*)))- 
A second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefonicid binds to penicillin-binding proteins… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (1)

Anti-Bacterial Agents
Cefonicid MonosodiumIn Bloodagonistsanalogs & derivatives
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Narrower (2)

MonocidSK&F-75073

Papers overview

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Highly Cited
2006
Highly Cited
2006
Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins.
Review
2002
Review
2002
Ceftriaxone: an update of its use in the management of community-acquired and nosocomial infections.
UNLABELLED Ceftriaxone is a parenteral third-generation cephalosporin with a long elimination half-life which permits once-daily… 
1998
1998
Prospective, randomized, double-blind study of prophylactic antibiotics in axillary lymph node dissection.
Highly Cited
1996
Highly Cited
1996
Short‐term versus long‐term antimicrobial prophylaxis in oncologic head and neck surgery
Although antimicrobial prophylaxis is mandatory in major clean‐contaminated oncologic surgery of the head and neck, both the… 
Highly Cited
1993
Highly Cited
1993
Randomized trial comparing ceftriaxone with cefonicid for treatment of spontaneous bacterial peritonitis in cirrhotic patients
We compared cefonicid (2 g every 12 h) and ceftriaxone (2 g every 24 h) for their efficacy and safety in treating spontaneous… 
Highly Cited
1990
Highly Cited
1990
Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery.
We assessed the efficacy of perioperative antibiotic prophylaxis for surgery in a randomized, double-blind trial of 1218 patients… 
Highly Cited
1990
Highly Cited
1990
Antibiotic prophylaxis: is there a difference?
Review
1984
Review
1984
Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use.
Ceftriaxone is a new 'third generation' semisynthetic cephalosporin with a long half-life which has resulted in a recommended… 
Highly Cited
1984
Highly Cited
1984
Failure of a once-daily regimen of cefonicid for treatment of endocarditis due to Staphylococcus aureus.
Cefonicid, a new long-acting cephalosporin, was evaluated for treatment of endocarditis due to Staphylococcus aureus. Four… 
1982
1982
Pharmacokinetics of cefonicid, a new broad-spectrum cephalosporin
This study determined the pharmacokinetic disposition of cefonicid. A single dose of 7.5 mg/kg of body weight was administered to… 
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