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Caspase Activation and Recruitment Domain

Known as: Recruitment Domains, Caspase, Caspase Activation and Recruitment Domains, CARD Domain 
A homotypic protein interaction module of the death domain superfamily. It is composed of a bundle of six alpha-helices that is related in sequence… 
National Institutes of Health

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2010
Highly Cited
2010
Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes
BackgroundThe apoptotic speck-like protein containing a caspase recruitment domain (ASC) is the essential adaptor protein for… 
Highly Cited
2009
Highly Cited
2009
Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain1
Activation of caspase 1 is essential for the maturation and release of IL-1β and IL-18 and occurs in multiprotein complexes… 
Highly Cited
2007
Highly Cited
2007
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be… 
Highly Cited
2007
Highly Cited
2007
Inflammasome-Mediated Production of IL-1β Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo1
IL-1R activation is required for neutrophil recruitment in an effective innate immune response against Staphylococcus aureus… 
Highly Cited
2003
Highly Cited
2003
Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation 1
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)/target of methylation-induced silencing… 
Highly Cited
2003
Highly Cited
2003
Requirement for CARMA1 in Antigen Receptor-Induced NF-κB Activation and Lymphocyte Proliferation
Highly Cited
2002
Highly Cited
2002
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
The immune system consists of two evolutionarily different but closely related responses, innate immunity and adaptive immunity… 
Review
2002
Review
2002
CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure.
The caspase recruitment domain gene (CARD15) was recently identified as the underlying gene associated with the IBD1 locus that… 
Review
2001
Review
2001
The death domain superfamily: a tale of two interfaces?
Highly Cited
2000
Highly Cited
2000
TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.
Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that… 
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