Caspase 12

Known as: Caspase 12 [Chemical/Ingredient], Caspase-12 
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 12 is activated by pro-apoptotic factors that… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
05010020002018

Papers overview

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Highly Cited
2006
Highly Cited
2006
Caspases function in both apoptosis and inflammatory cytokine processing and thereby have a role in resistance to sepsis. Here we… (More)
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Highly Cited
2005
Highly Cited
2005
Alterations in cellular homeostasis that affect protein folding in the endoplasmic reticulum (ER) trigger a signaling pathway… (More)
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Highly Cited
2004
Highly Cited
2004
Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could arise from dysfunction of the… (More)
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Highly Cited
2004
Highly Cited
2004
Recently, endoplasmic reticulum (ER) dysfunction has been implicated in neuronal death in patients with Alzheimer's disease… (More)
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Highly Cited
2003
Highly Cited
2003
Prion diseases are characterized by accumulation of misfolded prion protein (PrP(Sc)), and neuronal death by apoptosis. Here we… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of caspase-12 from procaspase-12 is specifically induced by insult to the endoplasmic reticulum (ER) (Nakagawa, T… (More)
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Highly Cited
2002
Highly Cited
2002
Caspase 12 has been cloned from rodent cells, in which it mediated apoptosis in response to endoplasmic reticulum stress. Based… (More)
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Highly Cited
2001
Highly Cited
2001
When accumulation of a malfolded protein in the endoplastic reticulum (ER) is induced by various adverse conditions, such as… (More)
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… (More)
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Highly Cited
2000
Highly Cited
2000
Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here… (More)
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