Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 area in mice following transient forebrain ischemia.

@article{Osada2010CharacterizationON,
  title={Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 area in mice following transient forebrain ischemia.},
  author={Nobuhiro Osada and Yasuhiro Kosuge and Kumiko Ishige and Yoshihisa Ito},
  journal={Neurochemistry international},
  year={2010},
  volume={57 1},
  pages={1-7}
}
Transient forebrain ischemia has been shown to cause neuronal injury in the CA1 area of the hippocampus in mice. In addition to neuronal injury, astrocytes in area CA1 undergo apoptosis under ischemic conditions. Although failure of impaired astrocytes to take up glutamate is thought to contribute to the pathogenesis of cerebral ischemia, the molecular mechanism underlying this phenomenon remains unexplored. In the present study, we investigated neuronal and astroglial responses to endoplasmic… CONTINUE READING

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