Canrenoate
National Institutes of Health
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SummaryWe investigated the effects of furosemide, a loop diuretic, and canrenoate, an aldosterone antagonist, on the endocochlear…
In the renal collecting duct (CD) the major physiological role of aldosterone is to promote Na+ reabsorption. In addition…
The renal response to a selective increase in the Na+ concentration of the blood perfusing the central nervous system was…
Canrenoate (Soldactone)--a spironolactone metabolite for intravenous use--has recently been suggested as a specific antidote in…
1. Serum concentrations of aldosterone in later fetal, 3‐6 week old and adult pigs are of the order of 300 pg ml.‐1. This…
Canrenoate, which has mineralocorticoid blocking activity, was evaluated in 3 normal subiects. The drug was administered by…
Summary Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased…