Author pages are created from data sourced from our academic publisher partnerships and public sources.
Inotropic action of digitalis and ion transport.
O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na+-K+-ATPase.
The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of… Expand
Concealed positive force-frequency relationships in rat and mouse cardiac muscle revealed by ryanodine.
Increases in stimulation frequency between 0.3 and 2 Hz decrease developed tension in rat, seemingly inconsistent with the explanation that an elevation of intracellular Na+-ion concentration is… Expand
Cloning and expression of human aldose reductase.
- C. Nishimura, Y. Matsuura, +5 authors T. G. Flynn
- Biology, Medicine
- The Journal of biological chemistry
- 15 June 1990
The complete amino acid sequence of human retina and muscle aldose reductase was determined by nucleotide analysis of cDNA clones isolated using synthetic oligonucleotide probes based on partial… Expand
Doxorubicin-induced late cardiotoxicity: delayed impairment of Ca2+-handling mechanisms in the sarcoplasmic reticulum in the rat.
- A. Chugun, K. Temma, +6 authors T. Akera
- Canadian journal of physiology and pharmacology
- 1 March 2000
Doxorubicin treatment causes delayed development of cardiotoxicity. Whether the doxorubicin-induced impairment of cardiac functions reverses or progresses with time after the cessation of the… Expand
Paradoxical positive inotropic effect of K+ in the rat heart.
In cardiac muscle isolated from most mammalian species, an elevation of extracellular K+ concentration decreases developed tension. This is explained from stimulation of the Na pump. In rat… Expand
Depressed Function of a Ouabain‐Sensitive Sodium‐Potassium Pump in Blood Vessels from Renal Hypertensive Dogs
- H. Overbeck, M. Pamnani, T. Akera, Theodore M. Brody, F. Haddy
- Circulation research
- 1 June 1976
Vasodilator responses to acute intra-arterial infusions of K+ are attenuated in dogs with chronic one-kidney perinephritic hypertension in rats with chronic two-kidney Goldblatt hypertension, and in… Expand
The role of Na+,K+-ATPase in the inotropic action of digitalis.
Membrane adenosinetriphosphatase: a digitalis receptor?
- T. Akera
- Biology, Medicine
- 11 November 1977
The enzyme Na+,K+-ATPase is a good model for receptor studies because of its known functional correlates. The binding of digitalis to the enzyme observed in vitro satisfied the criteria for receptor… Expand
The addiction cycle to narcotics in the rat and its relation to catecholamines.
Abstract Tolerance to and physical dependence on several narcotic analgesics were demonstrated in the rat. Daily doses of morphine at 30 and 120 mg kg and levorphanol at 6 and 15 mg kg given in… Expand