• Publications
  • Influence
Inotropic action of digitalis and ion transport.
  • 40
  • 4
O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na+-K+-ATPase.
  • M. Kim, T. Akera
  • Biology, Medicine
  • The American journal of physiology
  • 1 February 1987
The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers ofExpand
  • 180
  • 3
Concealed positive force-frequency relationships in rat and mouse cardiac muscle revealed by ryanodine.
Increases in stimulation frequency between 0.3 and 2 Hz decrease developed tension in rat, seemingly inconsistent with the explanation that an elevation of intracellular Na+-ion concentration isExpand
  • 62
  • 3
Cloning and expression of human aldose reductase.
The complete amino acid sequence of human retina and muscle aldose reductase was determined by nucleotide analysis of cDNA clones isolated using synthetic oligonucleotide probes based on partialExpand
  • 84
  • 2
Doxorubicin-induced late cardiotoxicity: delayed impairment of Ca2+-handling mechanisms in the sarcoplasmic reticulum in the rat.
Doxorubicin treatment causes delayed development of cardiotoxicity. Whether the doxorubicin-induced impairment of cardiac functions reverses or progresses with time after the cessation of theExpand
  • 26
  • 2
Paradoxical positive inotropic effect of K+ in the rat heart.
In cardiac muscle isolated from most mammalian species, an elevation of extracellular K+ concentration decreases developed tension. This is explained from stimulation of the Na pump. In ratExpand
  • 8
  • 2
Depressed Function of a Ouabain‐Sensitive Sodium‐Potassium Pump in Blood Vessels from Renal Hypertensive Dogs
Vasodilator responses to acute intra-arterial infusions of K+ are attenuated in dogs with chronic one-kidney perinephritic hypertension in rats with chronic two-kidney Goldblatt hypertension, and inExpand
  • 162
  • 1
The role of Na+,K+-ATPase in the inotropic action of digitalis.
  • 318
  • 1
Membrane adenosinetriphosphatase: a digitalis receptor?
  • T. Akera
  • Biology, Medicine
  • Science
  • 11 November 1977
The enzyme Na+,K+-ATPase is a good model for receptor studies because of its known functional correlates. The binding of digitalis to the enzyme observed in vitro satisfied the criteria for receptorExpand
  • 144
  • 1
The addiction cycle to narcotics in the rat and its relation to catecholamines.
Abstract Tolerance to and physical dependence on several narcotic analgesics were demonstrated in the rat. Daily doses of morphine at 30 and 120 mg kg and levorphanol at 6 and 15 mg kg given inExpand
  • 145
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