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CYT997

Known as: Tubulin Inhibitor CYT997 
 
National Institutes of Health

Papers overview

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2019
2019
BackgroundOsteosarcoma (OS) is a common malignant cancer in children and adolescents and has a cure rate that has not improved in… Expand
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2017
2017
BackgroundAbnormalities of tubulin polymerization and microtubule assembly are often seen in cancer, which make them very… Expand
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2013
2013
The orally active microtubule-depolymerizing agent CYT997 is potently cytotoxic to a variety of tumors in vitro and in vivo… Expand
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2012
2012
SummaryPurpose CYT997 is a novel microtubule inhibitor and vascular disrupting agent. This phase I trial examined the safety… Expand
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2011
2011
The orally active microtubule-disrupting agent (S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2… Expand
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2010
2010
Background:CYT997 is a novel microtubule inhibitor and vascular-disrupting agent with marked preclinical anti-tumour activity… Expand
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2009
2009
CYT997 is a wholly synthetic compound that possesses highly potent cytotoxic activity in vitro through inhibition of microtubule… Expand
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2009
2009
CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer… Expand
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2009
2009
SummaryMultiple Myeloma (MM) is an incurable malignancy of mature plasma cells. Microtubule targeting agents (MTAs) are an… Expand
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2009
2009
3568 Background: CYT997 is a novel, small-molecule vascular disrupting agent which binds tubulin and inhibits microtubule… Expand
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