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CYT997
Known as:
Tubulin Inhibitor CYT997
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Lexibulin
Pyridines
Pyrimidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective.
Md. Rezanur Rahman
,
T. Islam
,
+7 authors
M. Moni
Genomics
2020
Corpus ID: 199437398
2019
2019
Intracellular reduction in ATP levels contributes to CYT997‐induced suppression of metastasis of head and neck squamous carcinoma
Xiangdong Zhao
,
Liwei Lang
,
+6 authors
Yong Teng
Journal of Cellular and Molecular Medicine
2019
Corpus ID: 53948931
The incidence rate of head and neck squamous cell carcinoma (HNSCC) has steadily increased over the past decade. However…
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2018
2018
Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis
Lixia Gao
,
Xiangdong Zhao
,
Liwei Lang
,
C. Shay
,
W. Andrew Yeudall
,
Yong Teng
Journal of molecular medicine
2018
Corpus ID: 49865485
The functional relationship between apoptosis and autophagy in anticancer drug treatment is extremely complex, and the molecular…
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2017
2017
Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity
Yong Teng
,
Yafei Cai
,
W. Pi
,
Lixia Gao
,
C. Shay
Journal of Hematology & Oncology
2017
Corpus ID: 34245165
BackgroundAbnormalities of tubulin polymerization and microtubule assembly are often seen in cancer, which make them very…
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2013
2013
The microtubule depolymerizing agent CYT997 effectively kills acute myeloid leukemia cells via activation of caspases and inhibition of PI3K/Akt/mTOR pathway proteins
Xiaohui Chen
,
Chunmei Yang
,
Yan-hua Xu
,
Hui Zhou
,
Hui Liu
,
W. Qian
Experimental and Therapeutic Medicine
2013
Corpus ID: 17308980
The orally active microtubule-depolymerizing agent CYT997 is potently cytotoxic to a variety of tumors in vitro and in vivo…
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2012
2012
Phase I, pharmacokinetic and pharmacodynamic evaluation of CYT997, an orally-bioavailable cytotoxic and vascular-disrupting agent
M. burge
,
A. Francesconi
,
+5 authors
J. Lickliter
Investigational new drugs
2012
Corpus ID: 11545221
SummaryPurpose CYT997 is a novel microtubule inhibitor and vascular disrupting agent. This phase I trial examined the safety…
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2011
2011
The Microtubule Depolymerizing Agent CYT997 Causes Extensive Ablation of Tumor Vasculature In Vivo
C. Burns
,
E. Fantino
,
+12 authors
Gregg D Smith
Journal of Pharmacology and Experimental…
2011
Corpus ID: 5662732
The orally active microtubule-disrupting agent (S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2…
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2011
2011
CYT997 Causes apoptosis in human multiple myeloma
K. Monaghan
,
T. Khong
,
Gregg D Smith
,
A. Spencer
Investigational new drugs
2011
Corpus ID: 8770746
SummaryMultiple Myeloma (MM) is an incurable malignancy of mature plasma cells. Microtubule targeting agents (MTAs) are an…
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2010
2010
Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent
J. Lickliter
,
A. Francesconi
,
+11 authors
P. Vasey
British Journal of Cancer
2010
Corpus ID: 2672872
Background:CYT997 is a novel microtubule inhibitor and vascular-disrupting agent with marked preclinical anti-tumour activity…
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2009
2009
CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo
C. Burns
,
E. Fantino
,
+16 authors
A. Wilks
Molecular Cancer Therapeutics
2009
Corpus ID: 13596260
CYT997 is a wholly synthetic compound that possesses highly potent cytotoxic activity in vitro through inhibition of microtubule…
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