Skip to search formSkip to main contentSkip to account menu

CYT997

Known as: Tubulin Inhibitor CYT997 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

LexibulinPyridinesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective.
2019
2019
Intracellular reduction in ATP levels contributes to CYT997‐induced suppression of metastasis of head and neck squamous carcinoma
The incidence rate of head and neck squamous cell carcinoma (HNSCC) has steadily increased over the past decade. However… 
2018
2018
Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis
The functional relationship between apoptosis and autophagy in anticancer drug treatment is extremely complex, and the molecular… 
2017
2017
Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity
BackgroundAbnormalities of tubulin polymerization and microtubule assembly are often seen in cancer, which make them very… 
2013
2013
The microtubule depolymerizing agent CYT997 effectively kills acute myeloid leukemia cells via activation of caspases and inhibition of PI3K/Akt/mTOR pathway proteins
The orally active microtubule-depolymerizing agent CYT997 is potently cytotoxic to a variety of tumors in vitro and in vivo… 
2012
2012
Phase I, pharmacokinetic and pharmacodynamic evaluation of CYT997, an orally-bioavailable cytotoxic and vascular-disrupting agent
SummaryPurpose CYT997 is a novel microtubule inhibitor and vascular disrupting agent. This phase I trial examined the safety… 
2011
2011
The Microtubule Depolymerizing Agent CYT997 Causes Extensive Ablation of Tumor Vasculature In Vivo
The orally active microtubule-disrupting agent (S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2… 
2011
2011
CYT997 Causes apoptosis in human multiple myeloma
SummaryMultiple Myeloma (MM) is an incurable malignancy of mature plasma cells. Microtubule targeting agents (MTAs) are an… 
2010
2010
Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent
Background:CYT997 is a novel microtubule inhibitor and vascular-disrupting agent with marked preclinical anti-tumour activity… 
2009
2009
CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo
CYT997 is a wholly synthetic compound that possesses highly potent cytotoxic activity in vitro through inhibition of microtubule… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)