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CYC116

Known as: Aurora Kinase/VEGFR2 Inhibitor CYC116, CYC 116, CYC-116 
An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora… Expand
National Institutes of Health

Papers overview

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2018
2018
VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have… Expand
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2017
2017
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for the extracellular matrix (ECM) and… Expand
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2017
2017
Rationale: Fibrosis after lung injury is related to poor outcome, and idiopathic pulmonary fibrosis (IPF) can be regarded as an… Expand
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2017
2017
Vascular endothelial growth factor receptor-2 (VEGFR2) is the main pro-angiogenic receptor expressed by endothelial cells (ECs… Expand
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2016
2016
Antiangiogenic tyrosine kinase inhibitors (TKI) that target VEGF receptor-2 (VEGFR2) have not been effective as adjuvant… Expand
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2016
2016
Through both gain- and loss-of-TTF-1 expression strategies, we show that TTF-1 positively regulates vascular endothelial growth… Expand
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Highly Cited
2013
Highly Cited
2013
Thrombospondin-1 (TSP-1) inhibits growth factor signaling at the receptor level in microvascular endothelial cells (MVEC), and… Expand
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2010
2010
The angiogenic effects of 17beta-oestradiol (E(2)) in the mouse endometrium are mediated by vascular endothelial growth factor-A… Expand
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2008
2008
5645 Aurora kinases are key regulators of mitosis and cytokinesis and their upregulation has been associated with tumour genesis… Expand
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2006
2006
Angiogenesis following traumatic brain injuries (TBIs) may be of importance for post-traumatic reparative processes and the… Expand
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