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CYC116

Known as: Aurora Kinase/VEGFR2 Inhibitor CYC116, CYC 116, CYC-116 
An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora… Expand
National Institutes of Health

Papers overview

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2018
2018
Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1)
VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have… Expand
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2017
2017
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for the extracellular matrix (ECM) and… Expand
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2017
2017
Differential Expression of VEGF‐Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis
Rationale: Fibrosis after lung injury is related to poor outcome, and idiopathic pulmonary fibrosis (IPF) can be regarded as an… Expand
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2017
2017
Contribution of vascular endothelial growth factor receptor-2 sialylation to the process of angiogenesis
Vascular endothelial growth factor receptor-2 (VEGFR2) is the main pro-angiogenic receptor expressed by endothelial cells (ECs… Expand
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2016
2016
Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers.
Antiangiogenic tyrosine kinase inhibitors (TKI) that target VEGF receptor-2 (VEGFR2) have not been effective as adjuvant… Expand
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2016
2016
Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome
Through both gain- and loss-of-TTF-1 expression strategies, we show that TTF-1 positively regulates vascular endothelial growth… Expand
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Highly Cited
2013
Highly Cited
2013
Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells.
Thrombospondin-1 (TSP-1) inhibits growth factor signaling at the receptor level in microvascular endothelial cells (MVEC), and… Expand
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2010
2010
Vascular endothelial growth factor-A isoform and (co)receptor expression are differentially regulated by 17beta-oestradiol in the ovariectomised mouse uterus.
The angiogenic effects of 17beta-oestradiol (E(2)) in the mouse endometrium are mediated by vascular endothelial growth factor-A… Expand
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2008
2008
In vivo mode of action of CYC116, a novel small molecule inhibitor of Aurora kinases and VEGFR2
5645 Aurora kinases are key regulators of mitosis and cytokinesis and their upregulation has been associated with tumour genesis… Expand
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2006
2006
Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration.
Angiogenesis following traumatic brain injuries (TBIs) may be of importance for post-traumatic reparative processes and the… Expand
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