CYC116

Known as: Aurora Kinase/VEGFR2 Inhibitor CYC116, CYC 116, CYC-116 
An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2015
01220102015

Papers overview

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2015
2015
OBJECTIVE To investigate whether CYC116 can potentiate matrine-dependent growth inhibition and apoptosis in multiple myeloma (MM… (More)
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Review
2015
Review
2015
Aurora kinase A, B and C, are key regulators of mitosis and are over expressed in many of the human cancers, making them an ideal… (More)
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2013
2013
Drug resistance is the major obstacle to successful cancer therapy. Our study focuses on resistance to Aurora kinase inhibitors… (More)
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2010
2010
Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yl… (More)
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2010
2010
The spindle assembly checkpoint is a cell cycle surveillance mechanism that ensures the proper separation of chromosomes prior to… (More)
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