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CYC116

Known as: Aurora Kinase/VEGFR2 Inhibitor CYC116, CYC 116, CYC-116 
An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Efectos del sorafenib, un inhibidor tirosina quinasa, en el control del tono vascular
El carcinoma hepatocelular o hepatocarcinoma (HCC) es uno de los tumores solidos vasculares mas conocidos, representa uno de los… 
2018
2018
Endothelial VEGFR2 KO during CFA induced inflammation is detrimental to murine tibiotalar cartilage integrity
Review
2017
Review
2017
Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling
Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human… 
2017
2017
Abstract 3090: LY3207447, a tetravalent bispecific antibody targeting VEGFR2 and angiopoietin-2, provides a more efficient anti-angiogenic therapy and an alternative for combination
Angiopoietin-2 (Ang-2) is released from endothelial cells only in response to stimulus (e.g. wound healing, tumor growth) and… 
2016
2016
Abstract 3262: Effects of lenvatinib mesilate in combination with everolimus on VEGF and FGF-driven angiogenesis and tumor growth
Lenvatinib mesilate (lenvatinib) is an orally available inhibitor for multiple receptor tyrosine kinases (RTKs) that selectively… 
2015
2015
通心络抑制KK/Upj-Ay小鼠视网膜组织HIF-1a/VEGF/VEGFR-2表达
目的：观察通心络对自发糖尿病KK/Upj-Ay小鼠视网膜组织缺氧诱导因子-1a（HIF-1a）,血管内皮生长因子（VEGF）和血管内皮生长因子受体2（VEGFR2）基因及蛋白表达的影响,探讨通心络对糖尿病视网膜病变的保护机制。方法：40只KK/Upj-Ay… 
2014
2014
Gremlin, un nuevo mediador en la progresión de la enfermedad renal
Gremlin es un miembro de la superfamilia de TGF?? que actua como antagonista de las proteinas morfogeneticas de hueso (BMPs… 
2013
2013
Ocena ekspresji receptora VEGFR2 w nowotworach złośliwych ślinianek
2010
2010
An integrated pharmacokinetic–pharmacodynamic model for an Aurora kinase inhibitor
The spindle assembly checkpoint is a cell cycle surveillance mechanism that ensures the proper separation of chromosomes prior to… 
2008
2008
Systems biology analysis of a novel Aurora kinase inhibitor: CYC116
1645 Introduction Aurora kinases are known to play a role in mitotic entry, progression and exit. These kinases represent… 
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