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Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung.
Human interleukin 13 (IL-13) is a cytokine that has a profound effect on primary immune cells by inducing immunoglobulin production, proliferation of B cells, and the differentiation of cells of theExpand
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Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells.
The recognition of potentially harmful microorganisms involves the specific recognition of pathogen-associated molecular patterns (PAMPs) and the family of Toll-like receptors (TLRs) is known to playExpand
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A role for vascular endothelial growth factor in acute and resolving lung injury.
We have previously reported, in patients with acute respiratory distress syndrome (ARDS), elevated plasma levels of vascular endothelial growth factor (VEGF) that became reduced in those whoExpand
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Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome.
The development of noncardiogenic pulmonary edema is a characteristic feature of acute respiratory distress syndrome (ARDS). We hypothesized that vascular endothelial growth factor (VEGF) would playExpand
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Vascular endothelial growth factor (VEGF) in inflammatory and malignant pleural effusions
BACKGROUND Investigation and management of pleural effusions is an important clinical problem yet the pathogenesis of pleural fluid accumulation is poorly understood. Vascular endothelial growthExpand
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Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12 in a European population
BackgroundGenetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis of the pathogenesis ofExpand
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Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome.
BACKGROUND The adult respiratory distress syndrome (ARDS) may be regarded as an example of an uncontrolled or excessive inflammatory response in which tumour necrosis factor alpha (TNF-alpha) hasExpand
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Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), remains a devastating condition with a high mortality. It is characterised by alveolar injury andExpand
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Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity worldwide. While cigarette smoking is a major cause of COPD, only 15% of smokers develop the disease,Expand
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Differential expression of Toll‐like receptor (TLR)‐2 and TLR‐4 on monocytes in human sepsis
Toll‐like receptors (TLRs) are a recently described family of immune receptors involved in the recognition of pathogen‐associated molecular patterns (PAMPs). The central role of TLR‐2 and TLR‐4 inExpand
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