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CX3CR1 protein, human

Known as: Chemokine, CX3C Motif, Receptor 1, CMKBRL1 protein, human, Beta Chemokine Receptor-Like 1 
CX3C chemokine receptor 1 (355 aa, ~40 kDa) is encoded by the human CX3CR1 gene. This protein plays a role in cell adhesion, chemotaxis, cell defense… 
National Institutes of Health

Related topics

Related topics

26 relations
BrainCX3CR1 geneCell AdhesionCellular Stress Response

Broader (2)

chemokine receptorfractalkine receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis
Abstract Objective: Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1… 
Review
2014
Review
2014
Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
Microglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various… 
Highly Cited
2013
Highly Cited
2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy
Highly Cited
2012
Highly Cited
2012
Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease.
PURPOSE To determine cytokine and chemokine concentrations in the tears of patients with dry eye disease (DED) and analyze the… 
Highly Cited
2010
Highly Cited
2010
Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice
J. Neurochem. (2010) 114, 1143–1157. 
Highly Cited
2008
Highly Cited
2008
The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma.
Tumor perineural dissemination is a hallmark of human pancreatic ductal adenocarcinoma (PDAC) and represents a major source of… 
Review
2004
Review
2004
Mechanisms of leukocyte recruitment to atherosclerotic lesions: future prospects
Purpose of review Leukocyte invasion in the arterial wall is critical in the development of atherosclerotic lesions. This review… 
Highly Cited
2001
Highly Cited
2001
Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients.
Fractalkine is the only member of the CX3C chemokine family. Polymorphism of the fractalkine receptor gene may influence the… 
Highly Cited
1999
Highly Cited
1999
Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia.
Highly Cited
1982
Highly Cited
1982
Brunhes-Matuyama Magnetic Reversal Dated at 790,000 yr B.P. by Marine-Astronomical Correlations
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