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Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis.
In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the dentate gyrus give rise to newborn neuroblasts. However, only a small subset of these cells integrates into theExpand
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The Role of Microglia in the Healthy Brain
Microglia were recently shown to play unexpected roles in normal brain development and adult physiology. This has begun to dramatically change our view of these resident “immune” cells. Here, weExpand
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Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has aExpand
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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
Summary Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the preciseExpand
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Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.
Adult hippocampal neurogenesis is believed to maintain a range of cognitive functions, many of which decline with age. We recently reported that radial neural stem cells (rNSCs) in the hippocampusExpand
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Estradiol prevents kainic acid‐induced neuronal loss in the rat dentate gyrus
THE neuroprotective role of 17 β-estradiol in the hippocampal dentate gyrus of adult rats treated with kainic acid has been investigated. The systemic injection of a single low dose (7 mg/kg) ofExpand
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Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role in the diseased brain is poorly explored. Recent findings suggest thatExpand
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Adult Human Neurogenesis: From Microscopy to Magnetic Resonance Imaging
Neural stem cells reside in well-defined areas of the adult human brain and are capable of generating new neurons throughout the life span. In rodents, it is well established that the new bornExpand
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Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin‐like growth factor‐I signalling
We have previously shown that 17‐β‐estradiol protects neurons in the dentate gyrus from kainic acid‐induced death in vivo. To analyse whether this effect is mediated through estrogen receptors andExpand
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Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
Microglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various contexts of trauma, injury, and disease, where they are well-knownExpand
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