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CVT 313

Known as: CVT-313 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Purines

Papers overview

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2020
2020
Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313.
CVT-313 is a potent CDK2 inhibitor that was identified by screening a purine-analogue library and is currently in preclinical… 
2019
2019
Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38.
DNA damage activates checkpoints to arrest cell cycle progression in S and G2 phases, thereby providing time for repair and… 
2018
2018
A novel and effective inhibitor combination involving bortezomib and OTSSP167 for breast cancer cells in light of label-free proteomic analysis
The 26S proteasome plays important roles in many intracellular processes and is therefore a critical intracellular cellular… 
2016
2016
CDK1/2 toolbox in need of an upgrade
Cyclin-dependent protein kinases are key drivers of cell cycle progression. Specific phases of the cycle are controlled by… 
2012
2012
CDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species.
2008
2008
Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing
CDC5 proteins are components of the pre-mRNA splicing complex and essential for cell cycle progression in yeast, plants and… 
2006
2006
Tu-P8:308 Antiproliferative agent CVT-313 has a different impact on vascular smooth muscle cells from adult and newborn rats
Highly Cited
2001
Highly Cited
2001
Histone H1 Phosphorylation by Cdk2 Selectively Modulates Mouse Mammary Tumor Virus Transcription through Chromatin Remodeling
ABSTRACT Transcriptional activation of the mouse mammary tumor virus (MMTV) promoter by ligand-bound glucocorticoid receptor (GR… 
Highly Cited
1997
Highly Cited
1997
CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation*
The activity of cyclin-dependent kinase 2 (CDK2) is essential for progression of cells from G1 to the S phase of the mammalian… 
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