CTNNB1 gene

The canonical Wnt/β-catenin signaling pathway, an important modulator of progenitor cell proliferation and differentiation, is… Expand

Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Molecular… Expand

ABSTRACT Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the… Expand

The Wnt pathway controls numerous developmental processes via the beta-catenin-TCF/LEF transcription complex. Deregulation of the… Expand

Abstract As a component of adherens junctions and the Wnt signaling pathway, β-catenin binds cadherins, Tcf family transcription… Expand

Ectopic expression of certain Wnt genes in mouse mammary tissue is tumorigenic, and mutations that stabilize β‐catenin are found… Expand

Mutations in the adenomatous polyposis coli or beta-catenin gene lead to cytosolic accumulation of beta-catenin and, subsequently… Expand

The cytoplasmic proteins beta-catenin of vertebrates and armadillo of Drosophila have two functions: they link the cadherin cell… Expand

Vertebrate beta-catenin and Drosophila Armadillo share structural similarities suggesting that beta-catenin, like Armadillo, has… Expand

Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and… Expand