CTNNB1 gene

Known as: CTNNB1, Catenin (Cadherin-Associated Protein), Beta 1, 88kDa Gene, CADHERIN-ASSOCIATED PROTEIN, BETA 
This gene is involved in signal transduction and regulation of transcription.
National Institutes of Health

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Beta-Catenin-Activated Hepatocellular AdenomaCell AdhesionColorectal CarcinomaHepatoblastoma
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CTNNB1 wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.
Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Molecular… (More)
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Highly Cited
2008
Highly Cited
2008
Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors.
Wilms tumor is genetically heterogeneous, and until recently only one Wilms tumor gene was known, WT1 at 11p13. However, WT1 is… (More)
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Review
2005
Review
2005
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin.
Invasion by colorectal carcinomas is characterized by an epithelial-mesenchymal transition (EMT)-like dedifferentiation of the… (More)
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Highly Cited
2004
Highly Cited
2004
A mechanism for Wnt coreceptor activation.
LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are single-span transmembrane proteins… (More)
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Highly Cited
2002
Highly Cited
2002
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.
Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the… (More)
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Highly Cited
2001
Highly Cited
2001
PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
The Wnt-responsive transcription factor LEF1 can activate transcription in association with beta-catenin and repress… (More)
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Highly Cited
1999
Highly Cited
1999
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene.
Ectopic expression of certain Wnt genes in mouse mammary tissue is tumorigenic, and mutations that stabilize beta-catenin are… (More)
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Highly Cited
1999
Highly Cited
1999
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
Mutations in the adenomatous polyposis coli or beta-catenin gene lead to cytosolic accumulation of beta-catenin and, subsequently… (More)
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Highly Cited
1997
Highly Cited
1997
pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
Members of the Wnt/Wingless (Wg) family of signalling proteins organize many aspects of animal development by regulating the… (More)
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Highly Cited
1993
Highly Cited
1993
Association of the APC gene product with beta-catenin.
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and… (More)
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