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CRX-526

National Institutes of Health

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2 relations

Broader (1)

Glucosamine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Toll-like Rezeptor 4-Blockade bei experimenteller Endotoxinämie
Im Rahmen der Sepsis besitzt die Mikrozirkulation und insbesondere die intestinale Mikrozirkulation eine tragende Rolle in Bezug… 
2017
2017
Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-κB/IQGAP2 signaling pathway.
Inflammatory bowel disease (IBD) is characterized by a radical imbalance in the activation of proinflammatory and anti… 
2015
2015
Experimental TLR4 inhibition improves intestinal microcirculation in endotoxemic rats.
INTRODUCTION Toll like receptor 4 (TLR4) represents a critical cellular link for endotoxin-induced pathology. The aim of this… 
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2014
2014
The TLR4/NF-κB signaling pathway mediates the growth of colon cancer.
OBJECTIVE We studied the involvement of the TLR4/NF-κB pathway in the growth of colon cancer using human colon cancer specimens… 
2014
2014
There is an increasing trend in the The TLR 4 / NF-κ B signaling pathway mediates the growth of colon cancer
3834 Abstract. – OBJECTIVE: We studied the involvement of the TLR4/NF-κB pathway in the growth of colon cancer using human colon… 
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Highly Cited
2013
Highly Cited
2013
The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy.
We recently showed that Toll-like receptor (TLR) TLR4 was overexpressed in the human diabetic kidney, which could promote tubular… 
2010
2010
The TLR4 antagonist CRX-526 reduces LPS-induced leukocyte activation and improves capillary perfusion of the rat intestine
Toll-like receptor 4 (TLR4) represents an important mediator of endotoxin-related signal transduction. The aim of our study was… 
Highly Cited
2009
Highly Cited
2009
Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema.
Toll-like receptors (TLRs) of the innate immune system contribute to noninfectious inflammatory processes. We employed a murine… 
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2008
2008
The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics.
To overcome the chemical and metabolic instability of the secondary fatty acyl residues in the AGP class of lipid A mimetics, the… 
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Highly Cited
2005
Highly Cited
2005
A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease 1
Current evidence indicates that the chronic inflammation observed in the intestines of patients with inflammatory bowel disease… 
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