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Transferrin (Tf) conjugates of CRM107 are currently being tested in clinical trials for treatment of malignant gliomas. However… Expand Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it… Expand Previously a mathematical model was proposed that quantitatively related protein synthesis inhibition kinetics of antitransferrin… Expand Bispecific antibodies were designed to deliver a reversibly bound ligand into target cells and then spontaneously release it upon… Expand Targeted protein toxins are a new class of reagents with the potential for great tumor selectivity and cytotoxic potency. Two… Expand We have evaluated the sensitivity to immunotoxins (IT) of monolayer and of 200‐250 μM multicellular tumor spheroid (MTS) cultures… Expand CRM107 (crossreacting material 107), a double point mutant of diphtheria toxin that lacks receptor-binding activity, specifically… Expand Monoclonal antibodies linked to toxic proteins (immunotoxins) can selectively kill some tumor cells in vitro and in vivo. However… Expand