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CRM 107

Known as: CRM-107, CRM107 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Diphtheria Toxin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties
Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it… 
1998
1998
Quantitative analysis of protein synthesis inhibition and recovery in CRM107 immunotoxin-treated HeLa cells.
Previously a mathematical model was proposed that quantitatively related protein synthesis inhibition kinetics of antitransferrin… 
1997
1997
Intracellular Targeting with Low pH-triggered Bispecific Antibodies*
Bispecific antibodies were designed to deliver a reversibly bound ligand into target cells and then spontaneously release it upon… 
Highly Cited
1994
Highly Cited
1994
Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice.
Targeted protein toxins are a new class of reagents with the potential for great tumor selectivity and cytotoxic potency. Two… 
1994
1994
Cytoreductive effects of anti‐transferrin receptor immunotoxins in a multicellular tumor spheroid model
We have evaluated the sensitivity to immunotoxins (IT) of monolayer and of 200‐250 μM multicellular tumor spheroid (MTS) cultures… 
1990
1990
Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons.
CRM107 (crossreacting material 107), a double point mutant of diphtheria toxin that lacks receptor-binding activity, specifically… 
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