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CRM 107

Known as: CRM-107, CRM107 
 
National Institutes of Health

Papers overview

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2007
2007
Transferrin (Tf) conjugates of CRM107 are currently being tested in clinical trials for treatment of malignant gliomas. However… Expand
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Review
2006
Review
2006
Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it… Expand
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1998
1998
Previously a mathematical model was proposed that quantitatively related protein synthesis inhibition kinetics of antitransferrin… Expand
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1997
1997
Bispecific antibodies were designed to deliver a reversibly bound ligand into target cells and then spontaneously release it upon… Expand
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Highly Cited
1994
Highly Cited
1994
Targeted protein toxins are a new class of reagents with the potential for great tumor selectivity and cytotoxic potency. Two… Expand
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1994
1994
We have evaluated the sensitivity to immunotoxins (IT) of monolayer and of 200-250 microns multicellular tumor spheroid (MTS… Expand
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1990
1990
CRM107 (crossreacting material 107), a double point mutant of diphtheria toxin that lacks receptor-binding activity, specifically… Expand
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Highly Cited
1987
Highly Cited
1987
Monoclonal antibodies linked to toxic proteins (immunotoxins) can selectively kill some tumor cells in vitro and in vivo. However… Expand
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