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CREBBP protein, human

Known as: CREB binding protein, human, Phospho-CREB Binding Protein, CREB-Binding Protein 
CREB-binding protein (2442 aa, ~265 kDa) is encoded by the human CREBBP gene. This protein is involved in the mediation of histone acetylation.
National Institutes of Health

Related topics

Related topics

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CARM1 Transcription Regulation PathwayCREBBP geneCREBBP wt AlleleCell Cycle

Broader (1)

CREB-binding protein

Papers overview

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2020
2020
TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma
Abstract Recent studies have identified prognostic mutational clusters for diffuse large B-cell lymphoma (DLBCL) patients, both… 
2020
2020
High affinity between CREBBP/p300 and NCOA evolved in vertebrates
The interaction between the transcriptional coactivators CREBBP/p300 and NCOA is governed by two intrinsically disordered domains… 
2018
2018
Abstract 978: In vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer
The p300-CBP1 coactivator family members (CREB-binding protein (CREBBP) and E1A binding protein p300 (EP300)) share significant… 
2018
2018
Fragment-based drug design of bromodomain ligands
Epigenetic mechnisms are essential for normal development and alterations of epigenetic processe are correlated with many human… 
2017
2017
Low CREBBP expression is associated with adverse long‐term outcomes in paediatric acute lymphoblastic leukaemia
CREBBP alterations are associated with many diseases including leukaemia. However, CREBBP expression and its clinical relevance… 
2015
2015
Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia
A new study identifies recurrent mutations in the purine biosynthesis gene phosphoribosyl pyrophosphate synthetase 1 (PRPS1) in… 
2014
2014
Cation-π interactions play a key role in the binding of new CREBBP bromodomain inhibitors
2013
2013
Disruption of the CREBBP gene and decreased expression of CREB, NFκB p65, c-JUN, c-FOS, BCL2 and c-MYC suggest immune dysregulation.
2013
2013
Expressional and Mutational Analysis of CREBBP Gene in Gastric and Colorectal Cancers with Microsatellite Instability
To the Editor: The CREBBP gene encodes a protein CREBBP that binds with cAMP-response element (CRE)-binding protein [1]. The… 
2013
2013
Cervical Artery Dissection in a Young Patient with Rubinstein-Taybi Syndrome
The rubinstein-Taybi syndrome (rTs) is a genetic disorder defined by a combination of several congenital anomalies. The typical… 
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