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CRB1 protein, human

Known as: crumbs homolog 1 (Drosophila) protein, human, RP12 protein, human, crumbs protein, human 
National Institutes of Health

Related topics

Related topics

3 relations
CRB1 gene

Broader (2)

Membrane ProteinsNerve Tissue Proteins

Papers overview

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2019
2019
Crumbs proteins regulate layered retinal vascular development required for vision.
Review
2016
Review
2016
The Family of Crumbs Genes and Human Disease
The family of vertebrate Crumbs proteins, homologous to Drosophila Crumbs (Crb), share large extracellular domains with epidermal… 
2010
2010
GFAP-Driven GFP Expression in Activated Mouse Müller Glial Cells Aligning Retinal Blood Vessels Following Intravitreal Injection of AAV2/6 Vectors
Background Müller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because… 
Highly Cited
2008
Highly Cited
2008
Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.
Usher syndrome (USH) is a genetically heterogeneous group of autosomal recessive deaf-blinding disorders. Pathophysiology leading… 
2007
2007
Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex.
In human, mutations in tuberous sclerosis complex protein 1 or 2 (TSC1/2 or hamartin/tuberin) cause tuberous sclerosis… 
2006
2006
Pals1 Is Required for Correct Localization of Crb1 at the Sub–Apical Region in Müller Glia Cells
Purpose: Mutations in the human Crumbs homologue-1 (CRB1) gene cause retinal diseases including Leber congenital amaurosis (LCA… 
Review
2004
Review
2004
CRB1 mutation spectrum in inherited retinal dystrophies
Mutations in the Crumbs homologue 1 (CRB1) gene have been reported in patients with a variety of autosomal recessive retinal… 
Highly Cited
2002
Highly Cited
2002
The Carboxyl Terminus of Zona Occludens-3 Binds and Recruits a Mammalian Homologue of Discs Lost to Tight Junctions*
Mammalian homologues of theDrosophila polarity proteins Stardust, Discs Lost, and Crumbs have been identified as Pals1,Pals1… 
Highly Cited
2001
Highly Cited
2001
Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene.
Mutations in the crumbs homologue 1 (CRB1) gene cause a specific form of retinitis pigmentosa (RP) that is designated "RP12" and… 
Highly Cited
2001
Highly Cited
2001
CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.
Mutations in the human Crumbs homologue 1 (CRB1) gene cause severe retinal dystrophies, ranging from retinitis pigmentosa to… 
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