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Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules
The cargo that the molecular motor kinesin moves along microtubules has been elusive. We searched for binding partners of the COOH terminus of kinesin light chain, which contains tetratricopeptide… Expand
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
MANY of the actions of receptor tyrosine kinases are mediated by the protein Ras1–5, including the activation of various downstream serine/threonine kinases and the stimulation of growth and… Expand
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Two evolutionarily conserved multi-protein complexes,… Expand
Tight junctions and cell polarity.
- K. Shin, Vanessa C Fogg, B. Margolis
- Biology, Medicine
- Annual review of cell and developmental biology
- 9 October 2006
The tight junction is an intracellular junctional structure that mediates adhesion between epithelial cells and is required for epithelial cell function. Tight junctions control paracellular… Expand
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost
Membrane-associated guanylate kinase (Maguk) proteins are scaffold proteins that contain PSD-95–Discs Large–zona occludens-1 (PDZ), Src homology 3, and guanylate kinase domains. A subset of Maguk… Expand
Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein*
- M. Trommsdorff, J. Borg, B. Margolis, J. Herz
- Medicine, Biology
- The Journal of Biological Chemistry
- 11 December 1998
Apolipoprotein E, α2-macroglobulin, and amyloid precursor protein (APP) are involved in the development of Alzheimer’s disease. All three proteins are ligands for the low density lipoprotein (LDL)… Expand
Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.
IRS‐1 undergoes rapid tyrosine phosphorylation during insulin stimulation and forms a stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3′‐kinase, but p85 is not… Expand
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases] is mediated by Ras. Insulin activates Ras primarily by increasing… Expand
ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
The ERBB receptors have a crucial role in morphogenesis and oncogenesis. We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor… Expand
Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
Drosophila Crumbs is a transmembrane protein that plays an important role in epithelial cell polarity and photoreceptor development. Overexpression of Crumbs in Drosophila epithelia expands the… Expand