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CNKSR2 gene

Known as: CONNECTOR ENHANCER OF KSR 2, CNK2, CNKSR2 
 
National Institutes of Health

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KSR2 gene

Papers overview

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2020
2020
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK
Scaffold proteins are responsible for structural organisation within cells; they form complexes with other proteins to facilitate… Expand
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2019
2019
Expression analysis of LTR-derived miR-1269a and target gene, KSR2 in Sebastes schlegelii
BackgroundSebastes schlegelii are an important species of fish found in the coastal areas of the Korea with significant… Expand
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2018
2018
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression
BackgroundSmurf2 E3 ubiquitin ligase physically associates with and regulate the stability of distinct cellular protein… Expand
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2014
2014
The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE)
KSR2 is required for store-operated calcium entry (SOCE). KSR2 deficiency affects STIM1/ORAI1 puncta formation and cytoskeleton… Expand
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Highly Cited
2013
Highly Cited
2013
The Kinases LF4 and CNK2 Control Ciliary Length by Feedback Regulation of Assembly and Disassembly Rates
BACKGROUND Many of the diverse functions of cilia depend upon tight control of their length. Steady-state length reflects a… Expand
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2012
2012
Kinase Suppressor of Ras 2 (KSR2) Regulates Tumor Cell Transformation via AMPK
ABSTRACT Kinase suppressor of Ras 1 (KSR1) and KSR2 are scaffolds that promote extracellular signal-regulated kinase (ERK… Expand
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2011
2011
Loss-of-Function CNKSR2 Mutation Is a Likely Cause of Non-Syndromic X-Linked Intellectual Disability
In a non-dysmorphic 5-year-old boy with developmental delay, well-controlled epilepsy, and microcephaly, a 234-kb deletion of… Expand
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Highly Cited
2009
Highly Cited
2009
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals.
Protein scaffolds have emerged as important regulators of MAPK cascades, facilitating kinase activation and providing crucial… Expand
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Highly Cited
2009
Highly Cited
2009
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and… Expand
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Highly Cited
2003
Highly Cited
2003
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf 1
Connector enhancer of KSR (CNK) is a multidomain protein that participates in Ras signaling in Drosophila eye development. In… Expand
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