FAQ

CNKSR2 gene

Known as: CONNECTOR ENHANCER OF KSR 2, CNK2, CNKSR2 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2018
02420032018

Related topics

Related topics

1 relation
KSR2 gene

Related mentions per year

Related mentions per year

2002-2018
20002005201020152020
CNKSR2 gene
KSR2 gene

Papers overview

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Highly Cited
2016
Highly Cited
2016
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes
X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder. During the past two decades in… (More)
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2014
2014
Absent CNKSR2 causes seizures and intellectual, attention, and language deficits.
Synaptic function is central to brain function. Understanding the synapse is aided by studies of patients lacking individual… (More)
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2014
2014
Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner
Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to… (More)
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Highly Cited
2013
Highly Cited
2013
XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.
Because of the unbalanced sex ratio (1.3-1.4 to 1) observed in intellectual disability (ID) and the identification of large ID… (More)
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2013
2013
The Kinases LF4 and CNK2 Control Ciliary Length by Feedback Regulation of Assembly and Disassembly Rates
BACKGROUND Many of the diverse functions of cilia depend upon tight control of their length. Steady-state length reflects a… (More)
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2012
2012
Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK.
Kinase suppressor of Ras 1 (KSR1) and KSR2 are scaffolds that promote extracellular signal-regulated kinase (ERK) signaling but… (More)
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2012
2012
Loss-of-Function CNKSR2 Mutation Is a Likely Cause of Non-Syndromic X-Linked Intellectual Disability.
In a non-dysmorphic 5-year-old boy with developmental delay, well-controlled epilepsy, and microcephaly, a 234-kb deletion of… (More)
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2009
2009
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and… (More)
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2009
2009
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals.
Protein scaffolds have emerged as important regulators of MAPK cascades, facilitating kinase activation and providing crucial… (More)
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2003
2003
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
Connector enhancer of KSR (CNK) is a multidomain protein that participates in Ras signaling in Drosophila eye development. In… (More)
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