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CNI 1493

Known as: CNI-1493 
National Institutes of Health

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semapimod

Papers overview

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2011
2011
The role of CNI-1493 in the function of primary microglia with respect to amyloid-β.
Amyloid-β (Aβ) oligomer toxicity is a crucial factor in the development of Alzheimer's disease. Therefore, the aim of therapeutic… 
2009
2009
Simulations of IEF in microchannel with variable cross‐sectional area
This study develops a 1‐D mass transport model to describe the electrophoresis transport behavior within a microchannel with a… 
2008
2008
The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria—inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase
Malaria is still a major cause of death in the tropics. There is an urgent need for new anti-malarial drugs because drug… 
Review
2006
Review
2006
Biological therapies for inflammatory bowel disease: research drives clinics.
The better understanding of the mechanisms of inflammatory bowel disease has driven our progress into the development of new… 
2005
2005
Thrombotic microangiopathy in marginal kidneys after sirolimus use.
The increasing shortage of cadaver donor kidneys has prompted the use of expanded or marginal donor kidneys, ie, from older… 
2004
2004
Macrophage participation in influenza-induced sleep enhancement in C57BL/6J mice
1998
1998
CNI-1493 prolongs survival and reduces myocyte loss, apoptosis, and inflammation during rat cardiac allograft rejection.
Cytokines and cytotoxic agents, including nitric oxide (NO) released by macrophages, play important roles during cardiac… 
1998
1998
CNI‐1493 ATTENUATES HEMODYNAMIC AND PRO‐INFLAMMATORY RESPONSES TO LPS
The increased production of pro-inflammatory cytokines and nitric oxide have been postulated to contribute to the deleterious… 
1997
1997
Targeted suppression of cytokine production in monocytes but not in T lymphocytes by a tetravalent guanylhydrazone (CNI-1493).
Image analysis was used to study the cytokine-inhibitory effect of the nitric oxide inhibitor tetravalent guanylhydrazone (CNI… 
1997
1997
Protection against lethal polymicrobial sepsis by CNI-1493, an inhibitor of pro-inflammatory cytokine synthesis
Polymicrobial sepsis caused by cecal ligation and puncture (CLP) in mice produces the inflammatory and pathological sequelae of… 
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