Share This Author
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock.
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
It is reported that the nicotinic acetylcholine receptor α7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway.
The inflammatory reflex
- K. Tracey
- 19 December 2002
The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded understanding of how the nervous system modulates immune responses, and the opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems.
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
These features of HMGB1 are discussed and recent advances that have led to the preclinical development of therapeutics that modulateHMGB1 release and activity are summarized.
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes
- U. Andersson, Haichao Wang, K. Tracey
- Biology, MedicineJournal of Experimental Medicine
- 21 August 2000
Results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis.
HMGB1 is a therapeutic target for sterile inflammation and infection.
Experimental strategies that selectively target HMGB1 and TLR4 effectively reverse and prevent activation of innate immunity and significantly attenuate damage in diverse models of sterile and infection-induced threat.
Physiology and immunology of the cholinergic antiinflammatory pathway.
- K. Tracey
- Biology, MedicineJournal of Clinical Investigation
- 1 February 2007
This physiological, functional anatomical mechanism for neurological regulation of cytokine-dependent disease that begins to define an immunological homunculus is reviewed.
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
It is demonstrated that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process.
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Physiological anti-inflammatory mechanisms can potentially be exploited for the treatment of inflammatory disorders. Here we report that the neurotransmitter acetylcholine inhibits HMGB1 release from…
Reflex control of immunity
- K. Tracey
- BiologyNature reviews. Immunology
- 1 June 2009
It might be possible to develop therapeutics that target neural networks for the treatment of inflammatory disorders, including the cholinergic anti-inflammatory pathway, that modulate immune responses and the progression of inflammatory diseases.