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CLCN7 protein, human

Known as: CLC-7 chloride channel protein, human, Chloride Channel 7 Alpha Subunit, CLCN7 
H(+)/Cl(-) exchange transporter 7 (805 aa, ~89 kDa) is encoded by the human CLCN7 gene. This protein plays a role in proton-coupled, chloride anion… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Proteins of the CLC gene family assemble to homo- or sometimes heterodimers and either function as Cl(-) channels or as Cl(-)/H… Expand
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Highly Cited
2011
Highly Cited
2011
Mutations in the ClC-7/Ostm1 ion transporter lead to osteopetrosis and lysosomal storage disease. Its lysosomal localization… Expand
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2011
2011
Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fA… Expand
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Highly Cited
2010
Highly Cited
2010
During lysosomal acidification, proton-pump currents are thought to be shunted by a chloride ion (Cl-) channel, tentatively… Expand
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2009
2009
Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining… Expand
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Highly Cited
2008
Highly Cited
2008
Lysosomes are the stomachs of the cell—terminal organelles on the endocytic pathway where internalized macromolecules are… Expand
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2008
2008
Osteoclasts possess a large amount of ion transporters, which participate in bone resorption; of these, the vacuolar-adenosine… Expand
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2006
2006
ClC chloride channels (ClCs) can be classified into two groups in terms of their cellular localizations: ClCs present in the… Expand
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Highly Cited
2006
Highly Cited
2006
Mutations in ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, cause… Expand
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2004
2004
UNLABELLED We studied osteoclastic differentiation from normal and osteopetrotic human CD14 cells in vitro. Defects in acid… Expand
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