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CLCN7 protein, human

Known as: CLC-7 chloride channel protein, human, Chloride Channel 7 Alpha Subunit, CLCN7 
H(+)/Cl(-) exchange transporter 7 (805 aa, ~89 kDa) is encoded by the human CLCN7 gene. This protein plays a role in proton-coupled, chloride anion… Expand
National Institutes of Health

Related topics

Related topics

15 relations
Acid-Base EquilibriumCLCN7 geneCellular MembraneGated Ion Channel
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Broader (1)

Chloride Channels

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Cell biology and physiology of CLC chloride channels and transporters.
Proteins of the CLC gene family assemble to homo- or sometimes heterodimers and either function as Cl(-) channels or as Cl(-)/H… Expand
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Highly Cited
2011
Highly Cited
2011
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.
Mutations in the ClC-7/Ostm1 ion transporter lead to osteopetrosis and lysosomal storage disease. Its lysosomal localization… Expand
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2011
2011
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes
Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fA… Expand
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Highly Cited
2010
Highly Cited
2010
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
During lysosomal acidification, proton-pump currents are thought to be shunted by a chloride ion (Cl-) channel, tentatively… Expand
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2009
2009
Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice.
Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining… Expand
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Highly Cited
2008
Highly Cited
2008
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Lysosomes are the stomachs of the cell—terminal organelles on the endocytic pathway where internalized macromolecules are… Expand
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2008
2008
Ion Transporters Involved in Acidification of the Resorption Lacuna in Osteoclasts
Osteoclasts possess a large amount of ion transporters, which participate in bone resorption; of these, the vacuolar-adenosine… Expand
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2006
2006
Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers.
ClC chloride channels (ClCs) can be classified into two groups in terms of their cellular localizations: ClCs present in the… Expand
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Highly Cited
2006
Highly Cited
2006
ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function
Mutations in ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, cause… Expand
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2004
2004
In vitro differentiation of CD14 cells from osteopetrotic subjects: contrasting phenotypes with TCIRG1, CLCN7, and attachment defects.
UNLABELLED We studied osteoclastic differentiation from normal and osteopetrotic human CD14 cells in vitro. Defects in acid… Expand
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