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CLCN7 protein, human

Known as: CLC-7 chloride channel protein, human, Chloride Channel 7 Alpha Subunit, CLCN7 
H(+)/Cl(-) exchange transporter 7 (805 aa, ~89 kDa) is encoded by the human CLCN7 gene. This protein plays a role in proton-coupled, chloride anion… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Lysosomes must maintain an acidic luminal pH to activate hydrolytic enzymes and degrade internalized macromolecules… Expand
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Review
2012
Review
2012
Proteins of the CLC gene family assemble to homo- or sometimes heterodimers and either function as Cl(-) channels or as Cl(-)/H… Expand
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Highly Cited
2011
Highly Cited
2011
Mutations in the ClC‐7/Ostm1 ion transporter lead to osteopetrosis and lysosomal storage disease. Its lysosomal localization… Expand
Highly Cited
2011
Highly Cited
2011
Microglial lysosomes lack ClC-7, which leads to incomplete lysosomal acidification. In quiescent microglia, ClC-7 is targeted for… Expand
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Highly Cited
2010
Highly Cited
2010
Chloride Balancing Act The ionic composition of the cytosol and intracellular organelles must be regulated in the face of ongoing… Expand
2009
2009
Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining… Expand
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Highly Cited
2008
Highly Cited
2008
Lysosomes are the stomachs of the cell—terminal organelles on the endocytic pathway where internalized macromolecules are… Expand
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Highly Cited
2006
Highly Cited
2006
Mutations in ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, cause… Expand
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Highly Cited
2006
Highly Cited
2006
ClC chloride channels (ClCs) can be classified into two groups in terms of their cellular localizations: ClCs present in the… Expand
2004
2004
We studied osteoclastic differentiation from normal and osteopetrotic human CD14 cells in vitro. Defects in acid transport… Expand