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CLCN7 protein, human
Known as:
CLC-7 chloride channel protein, human
, Chloride Channel 7 Alpha Subunit
, CLCN7
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H(+)/Cl(-) exchange transporter 7 (805 aa, ~89 kDa) is encoded by the human CLCN7 gene. This protein plays a role in proton-coupled, chloride anion…
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National Institutes of Health
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Related topics
Related topics
15 relations
Acid-Base Equilibrium
CLCN7 gene
Cellular Membrane
Gated Ion Channel
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Broader (1)
Chloride Channels
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A model of lysosomal pH regulation
Yoichi Ishida
,
S. Nayak
,
J. Mindell
,
M. Grabe
The Journal of general physiology
2013
Corpus ID: 5744597
Lysosomes must maintain an acidic luminal pH to activate hydrolytic enzymes and degrade internalized macromolecules…
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Review
2012
Review
2012
Cell biology and physiology of CLC chloride channels and transporters.
T. Stauber
,
S. Weinert
,
T. Jentsch
Comprehensive Physiology
2012
Corpus ID: 4992928
Proteins of the CLC gene family assemble to homo- or sometimes heterodimers and either function as Cl(-) channels or as Cl(-)/H…
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Highly Cited
2011
Highly Cited
2011
ClC‐7 is a slowly voltage‐gated 2Cl−/1H+‐exchanger and requires Ostm1 for transport activity
Lilia Leisle
,
Carmen F. Ludwig
,
Florian A Wagner
,
T. Jentsch
,
T. Stauber
The EMBO journal
2011
Corpus ID: 266994
Mutations in the ClC‐7/Ostm1 ion transporter lead to osteopetrosis and lysosomal storage disease. Its lysosomal localization…
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Highly Cited
2011
Highly Cited
2011
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes
A. Majumdar
,
E. Capetillo-Zarate
,
Dana L Cruz
,
G. Gouras
,
F. Maxfield
Molecular biology of the cell
2011
Corpus ID: 15377865
Microglial lysosomes lack ClC-7, which leads to incomplete lysosomal acidification. In quiescent microglia, ClC-7 is targeted for…
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Highly Cited
2010
Highly Cited
2010
Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl– Accumulation
S. Weinert
,
S. Jabs
,
+7 authors
T. Jentsch
Science
2010
Corpus ID: 192043
Chloride Balancing Act The ionic composition of the cytosol and intracellular organelles must be regulated in the face of ongoing…
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2009
2009
Targeted disruption of the Cl−/HCO3− exchanger Ae2 results in osteopetrosis in mice
K. Josephsen
,
J. Praetorius
,
+5 authors
O. Fejerskov
Proceedings of the National Academy of Sciences
2009
Corpus ID: 36788032
Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining…
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Highly Cited
2008
Highly Cited
2008
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
A. Graves
,
P. Curran
,
Carolyn L. Smith
,
J. Mindell
Nature
2008
Corpus ID: 290664
Lysosomes are the stomachs of the cell—terminal organelles on the endocytic pathway where internalized macromolecules are…
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Highly Cited
2006
Highly Cited
2006
ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function
P. Lange
,
L. Wartosch
,
T. Jentsch
,
J. Fuhrmann
Nature
2006
Corpus ID: 4388429
Mutations in ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, cause…
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Highly Cited
2006
Highly Cited
2006
Intracellular localization of ClC chloride channels and their ability to form hetero‐oligomers
Tatsunori Suzuki
,
T. Rai
,
+5 authors
S. Uchida
Journal of cellular physiology
2006
Corpus ID: 8798468
ClC chloride channels (ClCs) can be classified into two groups in terms of their cellular localizations: ClCs present in the…
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2004
2004
In Vitro Differentiation of CD14 Cells From Osteopetrotic Subjects: Contrasting Phenotypes With TCIRG1, CLCN7, and Attachment Defects
H. Blair
,
C. Borysenko
,
+6 authors
P. Orchard
Journal of bone and mineral research : the…
2004
Corpus ID: 8057009
We studied osteoclastic differentiation from normal and osteopetrotic human CD14 cells in vitro. Defects in acid transport…
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