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CLCN3 gene

Known as: CLC3, chloride voltage-gated channel 3, CLCN3 
National Institutes of Health

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2 relations
CLCN1 geneClC-3 channel

Papers overview

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Highly Cited
2008
Highly Cited
2008
Suppression of ClC-3 channel expression reduces migration of nasopharyngeal carcinoma cells.
Highly Cited
2007
Highly Cited
2007
Small‐conductance Cl– channels contribute to volume regulation and phagocytosis in microglia
The shape and volume of microglia (brain immune cells) change when they activate during brain inflammation and become migratory… 
2007
2007
Endotoxin Priming of Neutrophils Requires NADPH Oxidase-generated Oxidants and Is Regulated by the Anion Transporter ClC-3*
Several soluble mediators, including endotoxin, prime neutrophils for an enhanced respiratory burst in response to subsequent… 
Highly Cited
2007
Highly Cited
2007
ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment
Resistance to anticancer drugs and consequent failure of chemotherapy is a complex problem severely limiting therapeutic options… 
2006
2006
ClC-3 chloride channel prevents apoptosis induced by thapsigargin in PC12 cells
Cell volume can be altered by two different ways, swelling and shrinkage. Cell swelling is regulated by volume-regulated Cl… 
Highly Cited
2001
Highly Cited
2001
Functional inhibition of native volume‐sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti‐ClC‐3 antibody
1 Intracellular dialysis of NIH/3T3 cells with a commercially available anti‐ClC‐3 polyclonal antibody (Ab) for ≈30 min… 
Highly Cited
2000
Highly Cited
2000
The role of ClC‐3 in volume‐activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition
1 A chloride current with mild outward rectification was induced in the native bovine non‐pigmented ciliary epithelial (NPCE… 
2000
2000
Intracellular cyclic AMP inhibits native and recombinant volume‐regulated chloride channels from mammalian heart
1 ClC‐3 encodes a volume‐regulated Cl− channel (ICl,vol) in heart. We studied the regulation of native and recombinant cardiac… 
Highly Cited
2000
Highly Cited
2000
Swelling-induced taurine release without chloride channel activity in Xenopus laevis oocytes expressing anion channels and transporters.
Highly Cited
1998
Highly Cited
1998
Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle.
Swelling-activated or volume-sensitive Cl- currents are found in numerous cell types and play a variety of roles in their… 
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