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CK-2017357

National Institutes of Health

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ImidazolesPyrazines

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tirasemtiv

Papers overview

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2012
2012
The Fast Skeletal Troponin Activator, CK-2017357, Increases Muscle Function and Survival in SOD1 (G93A) Mice; a Model of ALS (P05.169)
Objective: To examine the effects of CK-2017357 in a mouse model of ALS. Background CK-2017357 is a small molecule activator of… 
2012
2012
A Study To Evaluate Safety, and Tolerability of Repeated Doses of CK-2017357 (CK-357) in Patients with Amyotrophic Lateral Sclerosis (S25.005)
2012
2012
A Study To Evaluate Safety and Tolerability of CK-2017357 (CK-357) in Patients with Amyotrophic Lateral Sclerosis Using a Twice-Daily, Dose-Titration Regimen (P04.155)
Objective: The primary objective of this study was to determine the safety and tolerability of CK-357 as the dose was increased… 
2009
2009
The Fast Skeletal Troponin Activator, CK‐2017357, Increases Skeletal Muscle Force in‐vitro and in‐situ
CK‐2017357 is a member of a class of fast skeletal troponin activators that were identified by high throughput screening of… 
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