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CIC-DUX4 Fusion Protein Expression

Expression of a fusion protein that results from a t(4;19)(q35;q13) translocation, which involves the human genes CIC (capicua transcriptional… 
National Institutes of Health

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CIC geneCIC-DUX SarcomaDUX4 geneUndifferentiated Round Cell Sarcoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma
Significance Oncogenic transcription factors, such as the CIC-DUX4 fusion protein, constitute cancer-specific but highly… 
2020
2020
Superficial sarcomas with CIC rearrangement are aggressive neoplasms: A series of eight cases
CIC rearranged sarcomas have significant overlap with Ewing sarcoma, are aggressive, and typically present in deep soft tissue… 
2019
2019
Clinicopathologic features of undifferentiated round cell sarcomas of bone & soft tissues: An attempt to unravel the BCOR-CCNB3- & CIC-DUX4-positive sarcomas
Background & objectives: Certain genetically defined undifferentiated round cell sarcomas, namely BCOR-CCNB3 and CIC-DUX4… 
Highly Cited
2018
Highly Cited
2018
Development and Evaluation of a Pan-Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter Platform.
2018
2018
Sarcoma With CIC-DUX4 Gene Fusion
Recent molecular advances have identified a novel sarcoma defined molecularly by oncogenic fusion of the genes CIC and DUX4… 
Highly Cited
2017
Highly Cited
2017
DUX4 Immunohistochemistry Is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor
The histologic differential diagnosis of pediatric and adult round cell tumors is vast and includes the recently recognized… 
Highly Cited
2016
Highly Cited
2016
Defining Ewing and Ewing-like small round cell tumors (SRCT): The need for molecular techniques in their categorization and differential diagnosis. A study of 200 cases.
Review
2016
Review
2016
Round cell sarcoma with CIC‐DUX4 gene fusion: Discussion of the distinctive cytomorphologic, immunohistochemical, and molecular features in the differential diagnosis of round cell tumors
Undifferentiated round cell sarcomas are a heterogeneous group, and include tumors that resemble the Ewing sarcoma family… 
2016
2016
Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.
Review
2015
Review
2015
High-Grade Undifferentiated Small Round Cell Sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 Fusion: Emerging Entities of Soft Tissue Tumors with Unique Histopathologic Features – A Case Report and…
Patient: Female, 36 Final Diagnosis: Small cell sarcoma Symptoms: Mass to right upper thigh Medication: — Clinical Procedure… 
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