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CH 5132799

Known as: CH-5132799, CH5132799 
National Institutes of Health

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2 relations

Broader (2)

PyrimidinesSulfonamides

Papers overview

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2019
2019
Melanocortin type 4 receptor–mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats
α-Melanocyte–stimulating hormone (α-MSH) has been shown to be involved in nociception, but the underlying molecular mechanisms… 
2015
2015
Correction: First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
  • Clinical Cancer Research
  • 2015
  • Corpus ID: 36006376
2014
2014
First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
Purpose: This phase I dose-escalation study investigated the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), safety… 
2013
2013
P06.08FINAL RESULTS OF PHASE I STUDY OF THE ORAL CLASS I PI3K INHIBITOR CH5132799 IN PATIENTS WITH ADVANCED SOLID TUMOURS
2012
2012
A pharmacokinetic (PK) pharmacodynamic (PD) driven first-in-human study of the oral class I PI3K inhibitor CH5132799, in patients with advanced solid tumors.
3022 Background: The phosphatidylinositol 3-kinase (PI3K) pathway is a promising target in cancer. CH5132799 is a novel PI3K… 
Highly Cited
2011
Highly Cited
2011
The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations
Purpose: The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer… 
Highly Cited
2011
Highly Cited
2011
Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799.
2011
2011
Cancer Therapy : Preclinical The Selective Class I PI 3 K Inhibitor CH 5132799 Targets Human Cancers Harboring Oncogenic PIK 3 CA Mutations
Purpose: The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer… 
2010
2010
122 Novel class I PI3K inhibitor CH5132799: potential clinical application in rational combination with molecular targeted therapeutics
2010
2010
74 Novel class I PI3K inhibitor CH5132799: disruption of the activated PI3K signaling in PIK3CA mutants confers potent antitumor efficacy
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