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CGP 69846A

Known as: CGP69846A 
National Institutes of Health

Papers overview

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2004
2004
AbstractPurpose. To evaluate the pulmonary distribution of CGP69846A (ISIS 5132), a phosphorothioate oligonucleotide, following… 
Highly Cited
2001
Highly Cited
2001
Raf-1 is a serine/threonine kinase that functions as a critical effector of Ras-mediated signal transduction via the mitogen… 
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Highly Cited
1999
Highly Cited
1999
PURPOSE Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts as a downstream effector of Ras in the… 
Highly Cited
1999
Highly Cited
1999
Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors… 
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1998
1998
The effects of co-administering polyanions on the pharmacokinetics of a 20-mer phosphorothioate oligodeoxynucleotide (CGP 69846A… 
1998
1998
CGP 69846A (ISIS 5132) is an antisense phosphorothioate oligodeoxynucleotide which targets human C-raf kinase and is currently… 
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Highly Cited
1997
Highly Cited
1997
The pharmacokinetics, tissue distribution and metabolism of CGP 69846A, a 20-mer phosphorothioate oligodeoxynucleotide targeted… 
Highly Cited
1997
Highly Cited
1997
The plasma and tissue disposition of CGP 69846A (ISIS 5132) was characterized in male CD-1 mice following iv bolus injections… 
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Highly Cited
1997
Highly Cited
1997
A 20-mer phosphorothioate oligodeoxynucleotide (ODN) directed against human C-raf kinase (CGP 69846A or ISIS 5132) was analyzed… 
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Highly Cited
1996
Highly Cited
1996
To determine the mechanism of action responsible for the in vivo antitumor activity of a phosphorothioate antisense inhibitor…