CGP 52608

OBJECTIVES Melatonin may influence directly tumor cells through the specific binding sites. The best known melatonin binding… (More)

Oncostatic activity of CGP 52608 at concentrations 1 microM or lower, and cytotoxicity at 5 and 10 microM, are showed in central… (More)

The effects of melatonin and the thiazolinidinedione derivative CGP 52608 on apoptosis of Colon 38 cancer cells were investigated… (More)

The report shows that melatonin enhances IL-2 and IL-6 production by two human lymphocytic (Jurkat) and monocytic (U937) cell… (More)

The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present… (More)

Melatonin is reported to reduce proliferation in many cell types, but the effect is small and the results are inconsistent… (More)

The thiazolidinedione BRL 49653 and the thiazolidinedione derivative CGP 52608 are lead compounds of two pharmacologically… (More)

The pineal gland hormone melatonin is well known as a regulator of circadian rhythmicity, but has also other functions in the… (More)

This paper shows that melatonin is able to activate human Th1 lymphocytes by increasing the production of IL-2 and IFN-gamma in… (More)

Many important physiological functions are controlled by hormones via binding and activating members of the nuclear receptor… (More)