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CGP 48506

Known as: CGP-48506 
National Institutes of Health

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BA 41899

Papers overview

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2007
2007
Signalling mechanisms in contraction‐mediated stimulation of intracellular NO production in cat ventricular myocytes
In this study we sought to determine whether contractile activity has a role as a signalling mechanism in the activation of… 
2002
2002
Effects of the Ca2+ sensitizers EMD 57033 and CGP 48506 on myocardial contractility and Ca2+ transients in human ventricular and atrial myocardium
Ca2+-Sensitizer, wie z.B. EMD 57033 (EMD) und CGP 48506 (CGP) erhöhen die Kontraktionskraft ohne dabei den intrazellulären Ca2… 
2001
2001
Positive Inotropic Effects of Calcium Sensitizers on Normal and Failing Cardiac Myocytes
Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the… 
2000
2000
Overall cardiac functional effect of positive inotropic drugs with differing effects on relaxation.
Recent interest in so-called calcium-sensitizing positive inotropic drugs has highlighted the potential problem of a positive… 
1999
1999
Pharmacologic evaluation of isometric contraction-relaxation coupling indexes in rabbit ventricular muscle.
1997
1997
Differential effects of the Ca2+ sensitizers caffeine and CGP 48506 on the relaxation rate of rat skinned cardiac trabeculae.
During heart failure, force production by the heart decreases. This may be overcome by Ca2+-sensitizing drugs, which increase… 
1997
1997
Relaxation effect of CGP-48506, EMD-57033, and dobutamine in ejecting and isovolumically beating rabbit hearts.
Because it is not known whether ejection influences the negative effect of the Ca2+-sensitizing drugs on ventricular relaxation… 
1997
1997
Pharmacological profile of CGP 48506, a new positive inotropic agent
1996
1996
Ca2+ channel activation by CGP 48506, a new positive inotropic benzodiazocine derivative.
1996
1996
Ca2+ sensitization in idiopathic dilated human myocardium. Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazoci ne-2,4-dione, a novel purely Ca2…
(+)-(5-Methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1, 5-benzodiazocine-2,4-dione (CAS 165755-40-8, CGP 48506) is a novel Ca2… 
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