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CEP-11981

Known as: Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981 
An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential… 
National Institutes of Health

Related topics

Related topics

1 relation
Receptor Tyrosine Kinase Inhibition

Papers overview

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2015
2015
신규 항인간 Tie2 항체
[과제] 인간 Tie2에 결합하여, 인간 Tie2를 활성화시킴으로써 당뇨병 황반부종, 당뇨병 망막증 또는 중증 하지허혈을 예방 또는 치료하는 항인간 Tie2… 
2014
2014
The angiopoietin-TIE2 pathway is a potential therapeutic target in urothelial carcinoma.
BACKGROUND Angiopoietin/Tyrosine Kinase-2 (ANG/TIE2), Fibroblast Growth Factor-1 (FGFR1) and Vascular Endothelial Growth Factor… 
2013
2013
CEP-11981, a small molecule inhibitor of multiple angiogenic targets, in a preclinical system of urothelial carcinoma (UC).
293 Background: The systemic therapy of advanced UC has significant unmet needs. Angiogenesis appears to play a major tumorigenic… 
Review
2013
Review
2013
Targeting angiopoietin-2 signaling in cancer therapy
Introdcution: Over the past decade, several anti-angiogenic strategies have been devised to target a wide spectrum of… 
2009
2009
EFECTO DEL TRATAMIENTO CON INFLIXIMAB EN LAS CONCENTRACIONES SÉRICAS DE FACTORES SOLUBLES ANGIOGÉNICOS EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL
2007
2007
CEP-11981: A potent TIE-2/Pan-VEGF-R inhibitor with broad kinase inhibitory activity exhibits significant antitumor and antiangiogenic efficacy in preclinical tumor models
B264 The identification of novel anti-angiogenic agents with favorable drug-like properties and the ability to induce objective… 
2007
2007
CEP-11981: Identification of an orally bioavailable TIE-2/VEGF-R2 inhibitor with broad kinase inhibitory activity
C203 Orally bioavailable, dual inhibitors of TIE-2/VEGF-R2 were identified by elaborating the C3/N13 SAR around a fused… 
2004
2004
Pyrimidines a activite tie2 (tek)
L'invention concerne un compose de la formule (1) ou un sel de ce dernier, dans laquelle R1, R2, R3, R4, R5, R6, A, B, L, n et m… 
2003
2003
Tie2/Tek expression in breast carcinoma: correlations of immunohistochemical assays and long-term follow-up in a series of 909 patients.
The degree of angiogenesis in breast cancer has previously been shown to be an indicator of prognosis, and tumor microvasculature… 
2003
2003
Results Ang 2 and Tie 2 Immunoreactivity Is Induced in Capillaries and Postcapillary Venules of Cardiac Allografts
Background—Angiopoietin (Ang)–1 is an angiogenic growth factor that counteracts the permeability and proinflammatory effects of… 
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