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CEP-11981
Known as:
Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981
An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential…
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National Institutes of Health
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Related topics
Related topics
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Receptor Tyrosine Kinase Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
An open-label study to determine the maximum tolerated dose of the multitargeted tyrosine kinase inhibitor CEP-11981 in patients with advanced cancer
R. Pili
,
M. Carducci
,
Peter Brown
,
H. Hurwitz
Investigational new drugs
2014
Corpus ID: 14649715
SummaryBackground This phase I study evaluated the pharmacokinetics and pharmacodynamics of CEP-11981, an oral vascular…
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2014
2014
Peroxiredoxin 1 participates in ischemia‐triggered endothelial polarization
Wei‐feng Ye
,
Rongrong Tao
,
+6 authors
F. Han
CNS Neuroscience & Therapeutics
2014
Corpus ID: 5442362
The balance between endothelial cell survival and death plays a pivotal role in brain remodeling and repair after stroke [1…
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2014
2014
The angiopoietin-TIE2 pathway is a potential therapeutic target in urothelial carcinoma.
W. Jian
,
J. Levitt
,
S. Lerner
,
G. Sonpavde
Anticancer Research
2014
Corpus ID: 45314529
BACKGROUND Angiopoietin/Tyrosine Kinase-2 (ANG/TIE2), Fibroblast Growth Factor-1 (FGFR1) and Vascular Endothelial Growth Factor…
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2012
2012
Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2…
R. Hudkins
,
Nadine C. Becknell
,
+13 authors
B. Ruggeri
Journal of Medicinal Chemistry
2012
Corpus ID: 21598424
A substantial body of evidence supports the utility of antiangiogenesis inhibitors as a strategy to block or attenuate tumor…
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2009
2009
A mikroszatellita allélvesztés-vizsgálat diagnosztikai és az angiogén faktorok expressziójának prognosztikai szerepe húgyhólyagrákban
Szarvas Tibor
2009
Corpus ID: 58461346
A hugyholyagrak a masodik leggyakrabban előfordulo urologiai jellegű tumoros megbetegedes. A mai gyakorlatban kezelesenek modjat…
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2007
2007
CEP-11981: A potent TIE-2/Pan-VEGF-R inhibitor with broad kinase inhibitory activity exhibits significant antitumor and antiangiogenic efficacy in preclinical tumor models
B. Ruggeri
,
T. Underiner
,
+17 authors
J. L. Vaught
2007
Corpus ID: 85785133
B264 The identification of novel anti-angiogenic agents with favorable drug-like properties and the ability to induce objective…
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2005
2005
Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma.
S. Meunier-Carpentier
,
J. Dales
,
+6 authors
C. Charpin
International Journal of Oncology
2005
Corpus ID: 42453159
The degree of angiogenesis in breast cancer has previously been shown to be an indicator of prognosis, and tumor microvasculature…
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Highly Cited
2003
Highly Cited
2003
Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis
A. Nykänen
,
R. Krebs
,
+5 authors
K. Lemström
Circulation
2003
Corpus ID: 37889345
Background—Angiopoietin (Ang)–1 is an angiogenic growth factor that counteracts the permeability and proinflammatory effects of…
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2003
2003
Tie2/Tek expression in breast carcinoma: correlations of immunohistochemical assays and long-term follow-up in a series of 909 patients.
J. Dales
,
S. Garcia
,
+6 authors
C. Charpin
International Journal of Oncology
2003
Corpus ID: 24175738
The degree of angiogenesis in breast cancer has previously been shown to be an indicator of prognosis, and tumor microvasculature…
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2001
2001
Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2.
B. Murray
,
E. Padrique
,
C. Pinko
,
M. McTigue
Biochemistry
2001
Corpus ID: 38893005
Activation of receptor tyrosine kinases by autophosphorylation is one of the most common and critical transformations in signal…
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