CEP-11981

Known as: Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981 
An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2016
02420022016

Papers overview

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2016
2016
Angiopoietin-2 (ANG2) regulates blood vessel remodeling in many pathological conditions through differential effects on Tie2… (More)
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Review
2016
Review
2016
BACKGROUND Tyrosine kinase inhibitors (TKIs) have been developed during the last decade that target the vascular endothelial… (More)
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Review
2016
Review
2016
OBJECTIVE To explore the efficacy and safety of pazopanib in a 'real-world' setting in unselected patients, as data regarding… (More)
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2014
2014
Background This phase I study evaluated the pharmacokinetics and pharmacodynamics of CEP-11981, an oral vascular endothelial… (More)
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2013
2013
293 Background: The systemic therapy of advanced UC has significant unmet needs. Angiogenesis appears to play a major tumorigenic… (More)
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2012
2012
Background:A relevant percentage of patients with metastatic renal cell carcinoma develop intolerance to vascular endothelial… (More)
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2012
2012
A substantial body of evidence supports the utility of antiangiogenesis inhibitors as a strategy to block or attenuate tumor… (More)
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2011
2011
INTRODUCTION Angiopoietin-1 (Angpt1), the natural agonist ligand for the endothelial Tie2 receptor, is a non-redundant… (More)
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2009
2009
BACKGROUND TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore… (More)
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2002
2002
Tie2 is an endothelial receptor tyrosine kinase that is required for both embryonic vascular development and tumor angiogenesis… (More)
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