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CEM 101

Known as: CEM-101 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

MacrolidesTriazoles
Solithromycin

Papers overview

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Highly Cited
2014
Highly Cited
2014
In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against Macrolide-Resistant and -Susceptible Mycoplasma genitalium Strains
ABSTRACT Mycoplasma genitalium has become well established as an etiological agent of sexually transmitted infections, but due to… 
Highly Cited
2013
Highly Cited
2013
Randomized, Double-Blind, Multicenter Phase 2 Study Comparing the Efficacy and Safety of Oral Solithromycin (CEM-101) to Those of Oral Levofloxacin in the Treatment of Patients with Community…
ABSTRACT Solithromycin, a new macrolide, and the first fluoroketolide in clinical development, with activity against macrolide… 
Highly Cited
2012
Highly Cited
2012
Comparison of Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Solithromycin (CEM-101) in Healthy Adult Subjects
ABSTRACT The steady-state concentrations of solithromycin in plasma were compared with concomitant concentrations in epithelial… 
Highly Cited
2012
Highly Cited
2012
In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with…
ABSTRACT Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the… 
2011
2011
Synthesis and antibacterial activity of novel 4-aryl-[1,2,3]-triazole containing macrolides.
Highly Cited
2011
Highly Cited
2011
Pharmacokinetics of Solithromycin (CEM-101) after Single or Multiple Oral Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects
ABSTRACT The pharmacokinetics of orally administered solithromycin (CEM-101), a novel fluoroketolide, were evaluated in healthy… 
Highly Cited
2010
Highly Cited
2010
Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis
ABSTRACT We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, which belongs to the… 
2010
2010
CEM-101 Activity against Gram-Positive Organisms
ABSTRACT The in vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various… 
Highly Cited
2009
Highly Cited
2009
Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101
ABSTRACT MICs were determined for an investigational ketolide, CEM-101, and azithromycin, telithromycin, doxycycline… 
Highly Cited
2009
Highly Cited
2009
In Vitro Activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with Defined Macrolide Resistance Mechanisms
ABSTRACT CEM-101 had MIC ranges of 0.002 to 0.016 μg/ml against macrolide-susceptible pneumococci and 0.004 to 1 μg/ml against… 
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