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CDX2 Protein, human

Known as: Caudal-Type Homeobox Protein 2, caudal type homeo box transcription factor 2 protein, human, Caudal-Type Homeo Box Transcription Factor 2 
Homeobox protein CDX-2 (313 aa, ~34 kDa) is encoded by the human CDX2 gene. This protein is involved in transcription and intestinal morphogenesis.
National Institutes of Health

Related topics

Related topics

14 relations
CDX2 AntigenCDX2 geneCDX2 wt AlleleCell Nucleus

Broader (1)

CDX2 Transcription Factor

Papers overview

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Highly Cited
2008
Highly Cited
2008
Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo.
Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages. It is initiated via asymmetric divisions of… 
Highly Cited
2004
Highly Cited
2004
The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas
CDX2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the… 
Review
2003
Review
2003
Cdx2 Protein Expression in Normal and Malignant Human Tissues: An Immunohistochemical Survey Using Tissue Microarrays
Cdx2 has been identified as a marker of colon cancer in RNA-profiling experiments. We show here that the detection of Cdx2… 
Highly Cited
2003
Highly Cited
2003
Cdx2 as a Marker of Epithelial Intestinal Differentiation in the Esophagus
The histologic diagnosis of Barrett's esophagus requires the presence of goblet cells, but this finding may not be the earliest… 
Highly Cited
2003
Highly Cited
2003
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
Background: During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary… 
Highly Cited
2002
Highly Cited
2002
Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation.
Mouse Cdx and Hox genes presumably evolved from genes on a common ancestor cluster involved in anteroposterior patterning… 
Highly Cited
2002
Highly Cited
2002
Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of…
Sucrase-isomaltase (SI), an intestine-specific gene, is induced in the differentiated small intestinal villous epithelium during… 
Highly Cited
2002
Highly Cited
2002
Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach.
Highly Cited
1998
Highly Cited
1998
Expression of the Cdx1 and Cdx2 Homeotic Genes Leads to Reduced Malignancy in Colon Cancer-derived Cells*
We have previously described an inverse relationship between Cdx1 and Cdx2 mRNA levels and the extent of dysplasia and severity… 
Highly Cited
1997
Highly Cited
1997
Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down‐regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
Defining the molecular mechanisms involved in cancer formation and progression is still a major challenge in colorectal‐cancer… 
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