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Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos
Summary The major and essential objective of pre-implantation development is to establish embryonic and extra-embryonic cell fates. To address when and how this fundamental process is initiated inExpand
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Self-Organization of the Human Embryo in the Absence of Maternal Tissues
The failure of an embryo to implant into the womb is a major cause of early pregnancy loss. The human embryo must implant into the uterus on the seventh day of development to survive and to developExpand
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Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo.
Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages. It is initiated via asymmetric divisions of eight- and 16-cell blastomeres that allocate cells to inner and outerExpand
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The first cleavage of the mouse zygote predicts the blastocyst axis
One of the unanswered questions in mammalian development is how the embryonic–abembryonic axis of the blastocyst is first established. It is possible that the first cleavage division contributes toExpand
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Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo
Divisions of polarised blastomeres that allocate polar cells to outer and apolar cells to inner positions initiate the first cell fate decision in the mouse embryo. Subsequently, outer cellsExpand
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Self-organisation of the human embryo in the absence of maternal tissues
Remodelling of the human embryo at implantation is indispensable for successful pregnancy. Yet it has remained mysterious because of the experimental hurdles that beset the study of thisExpand
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BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo
Pre-implantation development requires the specification and organization of embryonic and extra-embryonic lineages. The separation of these lineages takes place when asymmetric divisions generateExpand
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Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In response to extracellular matrix signalling, these cells undergo epithelialization and create an apicalExpand
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The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos
Lineage specification in the preimplantation mouse embryo is a regulative process. Thus, it has been difficult to ascertain whether segregation of the inner-cell-mass (ICM) into precursors of theExpand
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