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CDP323

National Institutes of Health

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Phenylalanine
analogs & derivatives

Papers overview

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Review
2018
Review
2018
α4β7 integrin inhibitors: a patent review
ABSTRACT Introduction: The α4β7 integrin is heterodimeric cell surface receptors expressed on most leukocytes. Mucosal addressing… 
2014
2014
In Vitro Hydrolysis and Transesterification of CDP323, an α4β1/α4β7 Integrin Antagonist Ester Prodrug
We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its… 
2013
2013
Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects: A Randomized, Double-Blind Phase 1/2 Study
Background Lymphocyte inhibition by antagonism of α4 integrins is a validated therapeutic approach for relapsing multiple… 
2013
2013
In Vitro Hydrolysis and Transesterification of CDP 323 , an a 4 b 1 / a 4 b 7 Integrin Antagonist Ester Prodrug
We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its… 
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