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CDP323

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phenylalanine
analogs & derivatives

Papers overview

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Review
2018
Review
2018
α4β7 integrin inhibitors: a patent review
ABSTRACT Introduction: The α4β7 integrin is heterodimeric cell surface receptors expressed on most leukocytes. Mucosal addressing… Expand
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2014
2014
In Vitro Hydrolysis and Transesterification of CDP323, an α4β1/α4β7 Integrin Antagonist Ester Prodrug
We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its… Expand
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2013
2013
Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects: A Randomized, Double-Blind Phase 1/2 Study
BACKGROUND Lymphocyte inhibition by antagonism of α4 integrins is a validated therapeutic approach for relapsing multiple… Expand
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2013
2013
In Vitro Hydrolysis and Transesterification of CDP 323 , an a 4 b 1 / a 4 b 7 Integrin Antagonist Ester Prodrug
We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its… Expand
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