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CDKN1C wt Allele

Known as: BWS, KIP2 Gene, KIP2 
Human CDKN1C wild-type allele located in the vicinity of 11p15.5 and is approximately 2 kb in length. This allele, which encodes cyclin-dependent… 
National Institutes of Health

Related topics

Related topics

7 relations
11p15.5Beckwith-Wiedemann SyndromeCell Cycle ControlHomo sapiens

Broader (1)

CDKN1C gene

Papers overview

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Review
2011
Review
2011
The hallmarks of CDKN1C (p57, KIP2) in cancer.
Highly Cited
2000
Highly Cited
2000
p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19.
1999
1999
Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome
Abstract p57KIP2 is a potent tight-binding inhibitor of several G1 cyclin/cyclin-dependent kinase (Cdk) complexes, and is a… 
1999
1999
A human p57(KIP2) transgene is not activated by passage through the maternal mouse germline.
Genomic imprinting results in expression of some autosomal genes from one parental allele only. Human chromosome 11p15, and the… 
1999
1999
P57 (KIP2) polymorphisms and breast cancer risk
A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57… 
Highly Cited
1997
Highly Cited
1997
Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors.
The Beckwith-Wiedemann syndrome (BWS) is marked by fetal organ overgrowth and conveys a predisposition to certain childhood… 
Highly Cited
1997
Highly Cited
1997
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
In situ hybridization of mouse embryo sections demonstrated expression of mRNAs encoding two polypeptide inhibitors (p18INK4c and… 
Highly Cited
1996
Highly Cited
1996
Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors.
The imprinted H19 gene is frequently inactivated in Wilms' tumors (WTs) either by chromosome 11p15.5 loss of heterozygosity (LOH… 
Review
1996
Review
1996
Genomic imprinting and Wilms' tumor.
The selective loss of maternal and reduplication of paternal chromosome 11p15.5 alleles in Wilms' tumors (WTs) points to the… 
1996
1996
Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors.
Mammalian cyclin-dependent kinase inhibitors fall into two families, the INK4 and the CIP/KIP. The CIP/KIP family comprises three… 
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