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CDK12 gene
Known as:
Cyclin-Dependent Kinase 12 Gene
, CDC2-RELATED KINASE WITH AN ARGININE/SERINE-RICH DOMAIN
, CDC2-RELATED PROTEIN KINASE 7
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This gene is involved in protein phosphorylation, RNA splicing and transcription elongation.
National Institutes of Health
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Related topics
Related topics
6 relations
CDK12 protein, human
Cell Cycle Control
Phosphorylation
RNA Splicing
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
CDK12 Loss a Biomarker for Prostate Cancer Response to Immunotherapy
B. Furlow
2018
Corpus ID: 145982243
DNA and RNA sequencing results suggest prostate cancer treatment “involving inhibition of CDK12 and immune checkpoint blockade…
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2018
2018
Abstract 2384: Preclinical evaluation of PD and efficacy of novel potent selective and orally bioavailable CDK12 covalent inhibitors in TNBC model
Ramulu Poddutoori
,
S. Rajagopalan
,
+18 authors
S. Samajdar
Molecular and Cellular Biology / Genetics
2018
Corpus ID: 81574532
Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase that participates in various cellular processes such as…
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2017
2017
Abstract 2352: Effect of inhibition of cell cycle versus transcription cyclin-dependent kinases (CDKs) in ovarian cancer cells
Rosaria Chilà
,
N. Panini
,
E. Erba
,
G. Damia
,
M. Broggini
2017
Corpus ID: 80248633
Background. Cell cycle is regulated by cyclin-dependent kinases (CDKs) activity, whose deregulation can lead to uncontrolled…
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2017
2017
Abstract 508: DNA repair status in a patient derived ovarian cancer xenobank
F. Guffanti
,
M. Fratelli
,
+8 authors
G. Damia
2017
Corpus ID: 80285834
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy with a 5-year relative survival rate of 45%. The high…
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2016
2016
Cdk 12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome , Including Nrf 2 Target Genes
Xuan Li
,
Nirmalya Chatterjee
,
Kerstin Spirohn
,
M. Boutros
,
D. Bohmann
2016
Corpus ID: 42632740
The Nrf2 transcription factor is well conserved throughout metazoan evolution and serves as a central regulator of adaptive…
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2016
2016
Abstract A09: Targeting chemoresistant ovarian malignancies to cytostatic drugs and PARP inhibitors by inhibition of CDK12 kinase activity.
J. Kohoutek
,
M. Svoboda
,
D. Vrábel
,
H. Paculova
,
M. Dzimkova
2016
Corpus ID: 77353021
Ovarian cancer ranks fifth in cancer deaths among women in the USA. After surgery, women are subjected to a combined treatment…
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Review
2014
Review
2014
Current Possible Drug Therapies for Ovarian Cancer
J. Seoung
,
Young-Han Park
,
C. Rhim
,
Sungjoo Kim
2014
Corpus ID: 53309419
Ovarian cancer is the most aggressive gynecologic cancer of the heterogenous phenotypes. Development of the new…
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Review
2014
Review
2014
[Function of CDK12 in Tumor initiation and progression and its clinical consequences].
D. Vrábel
,
M. Svoboda
,
J. Navrátil
,
J. Kohoutek
Klinicka onkologie
2014
Corpus ID: 11324804
Cyclin-dependent kinases (CDKs) participate in many cellular processes and play a crucial role in the regulation of cell cycle…
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2014
2014
Inhibitors Cisplatin and Poly ( ADP-ribose ) Polymerase Recombination Repair and Resistance to Kinase That Promotes Homologous Disable Catalytic Activity of CDK 12 , a Ovarian Cancer-associated…
Poorval Joshi
,
S. Sutor
,
C. Huntoon
,
L. Karnitz
2014
Corpus ID: 207759604
2013
2013
CDK12 IS A NOVEL ONCOGENE WITH CLINICAL AND PATHOGENETIC RELEVANCE IN BREAST CANCER
A. Taglialatela
2013
Corpus ID: 74507751